金催化的环丙叉缩醛丙炔醇的串联环化反应：一种构建官能化萘并[2,3-c]吡喃的方法。
Gold(i)-catalyzed tandem cyclization of cyclopropylidene-tethered propargylic alcohols: an approach to functionalized naphtho[2,3-c]pyrans.
机构信息
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, Shaanxi, P. R. China.
出版信息
Chem Commun (Camb). 2020 Aug 11;56(64):9154-9157. doi: 10.1039/d0cc03285a.
An unprecedented gold(i)-catalyzed cyclization of cyclopropylidene-tethered propargylic alcohols via a 6-endo-dig enyne cyclization followed by a ring-opening of cyclopropane and nucleophilic closure reaction to construct naphtho[2,3-c]pyrans was developed. This transformation represents a highly efficient method for the synthesis of polycyclic compounds in one-pot, and two new rings are formed in an atom economic manner.
发展了一种前所未有的金(i)催化环化反应，通过 6-endo-dig 烯炔环化反应和随后的环丙烷开环、亲核闭环反应，将环丙叉基丙炔醇环化，构建萘并[2,3-c]吡喃。这种转化代表了一种在一锅法中高效合成多环化合物的方法，以原子经济性的方式形成两个新环。
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