Wolters E C, Kebabian J C, Guttman M, Mak E, Pate B D, Calne D B
Department of Medicine, Health Sciences Centre Hospital, University of British Columbia, Vancouver, Canada.
Neurosci Lett. 1988 Dec 19;95(1-3):257-61. doi: 10.1016/0304-3940(88)90667-2.
Non-human primates exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) have been employed to study the clinical features of parkinsonism. Monkeys lesioned by unilateral intracarotid administration of MPTP display spontaneous and drug responsive turning behavior. However this seems to correlate poorly with their clinical deficits. We describe an objective measurement of arm movement velocity, applied in 4 cynomolgus monkeys before and after unilateral administration of MPTP. Reduced movement velocities correlated with clinical signs of unilateral flexed arm posture, rigidity, tremor and bradykinesia and could be reversed with L-DOPA therapy. This measurement technique has advantages for the quantitative assessment of parkinsonian deficits and will permit the evaluation of dopaminergic therapy and transplantation in non-human primates.
非人类灵长类动物暴露于1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）下已被用于研究帕金森症的临床特征。通过单侧颈动脉注射MPTP造成损伤的猴子表现出自发性和药物反应性的旋转行为。然而，这似乎与它们的临床缺陷相关性较差。我们描述了一种用于测量手臂运动速度的客观方法，该方法应用于4只食蟹猴在单侧注射MPTP前后。运动速度降低与单侧屈臂姿势、僵硬、震颤和运动迟缓的临床症状相关，并且可以通过左旋多巴治疗得到逆转。这种测量技术对于帕金森症缺陷的定量评估具有优势，并将有助于评估非人类灵长类动物中的多巴胺能治疗和移植情况。
