Ministry of Science and Innovation.
Ministry of Health, Consumer Affairs and Social Welfare.
Eur J Gastroenterol Hepatol. 2021 Oct 1;33(10):1307-1315. doi: 10.1097/MEG.0000000000001841.
This work evaluates the burden and trends of hepatitis C virus (HCV)-associated hospitalisations in Spain before and after the implementation of the Strategic Plan for Tackling Hepatitis C in the National Health System in 2015.
HCV-related hospitalisation discharges from 2005 to 2017 were obtained from the National Registry of Hospitalisations. A descriptive analysis of the hospitalisations was performed.
From 2005 to 2017, there were 674 067 HCV-related hospitalisations: 1.2%, 29.9%, 63.9% and 5% of them due to acute, carriers, chronic and unspecified hepatitis C. Average age of the patients was 57.7 years (SD: 16.4), average hospital stay was 9.1 days (SD: 12.2) and intra-hospital case-fatality rate was 6.5%. Hospitalisation rates decreased notably (P < 0.05) in 2016-2017 compared to 2005-2015 for all [hospitalisation rate ratio (HRR): 0.77], males (HRR: 0.80), females (HRR: 0.74), chronic hepatitis C (HRR: 0.84), non-advanced liver disease (N-AdLD) (HRR: 0.80) and AdLD (HRR: 0.73). Acute HCV (HRR: 0.54) and carriers (HRR: 0.49) show decreases in 2016-2017 vs. 2005-2015, although their rates started to decrease in 2008/2009. Unspecified HCV hospitalisation rates increased (P < 0.05) in 2016-2017 (HRR: 2.02) vs. 2005-2015. From 2015 to 2017, cost per patient increased from 5981 euros to 6349 euros, but overall cost decreased, as hospitalisations rates decreased from 302 to 264 million euros.
HCV-related hospitalisation rates decreased notably in 2016 and 2017 after the strategic plan for tackling hepatitis C was launched. Although cost per AdLD patient increased in 2016 and 2017, globally costs were reduced around 35 million euros per year.
本研究评估了西班牙在 2015 年国家卫生系统实施抗击丙型肝炎战略计划前后丙型肝炎病毒（HCV）相关住院治疗的负担和趋势。
从国家住院登记处获得了 2005 年至 2017 年 HCV 相关住院患者的出院记录。对住院情况进行了描述性分析。
2005 年至 2017 年期间，共有 674067 例 HCV 相关住院患者：1.2%、29.9%、63.9%和 5%分别因急性、携带者、慢性和未明确的丙型肝炎住院。患者平均年龄为 57.7 岁（标准差：16.4），平均住院时间为 9.1 天（标准差：12.2），院内病死率为 6.5%。与 2005-2015 年相比，2016-2017 年所有患者（住院率比值[HRR]：0.77）、男性（HRR：0.80）、女性（HRR：0.74）、慢性丙型肝炎（HRR：0.84）、非进展性肝病（N-AdLD）（HRR：0.80）和进展性肝病（AdLD）（HRR：0.73）的住院率均显著下降（P < 0.05）。急性 HCV（HRR：0.54）和携带者（HRR：0.49）的住院率在 2016-2017 年开始下降，但在 2008-2009 年开始下降。2016-2017 年未明确 HCV 的住院率（HRR：2.02）较 2005-2015 年有所增加（P < 0.05）。2015 年至 2017 年，每位患者的费用从 5981 欧元增加到 6349 欧元，但由于住院率从 3.02 亿降至 2.64 亿，总体费用减少。
在实施抗击丙型肝炎战略计划后，2016 年和 2017 年 HCV 相关住院率显著下降。尽管 2016 年和 2017 年每位 AdLD 患者的费用有所增加，但每年可减少约 3500 万欧元的费用。
