Mikisková H, Frantík E
Institute of Hygiene and Epidemiology, Centre of Industrial Medicine and Occupational Diseases, Praha.
Act Nerv Super (Praha). 1988 Dec;30(4):247-53.
Two animal models for testing foreign substances for the hypoxic type of cardiotoxicity proved to be valid and reproducible: i.e. decreased reserve capacity of the heart in rats recovered from the calciferol cardiopathy and increased heart work provoked by isoproterenol (5 mg/kg i.p.). In both cases obvious hypoxic ECG changes appeared at lower levels of exposure to carbon monoxide (500 ppm, 572 mg.m-3) and carboxyhemoglobin (18%), when compared with nonpretreated animals. The models have shown, that injured or overloaded heart displays a substantially increased sensitivity to CO poisoning.
即从钙化醇性心脏病恢复后的大鼠心脏储备能力下降，以及异丙肾上腺素（腹腔注射5毫克/千克）引起的心脏工作量增加。在这两种情况下，与未预处理的动物相比，在接触较低水平的一氧化碳（500 ppm，572毫克·米-3）和碳氧血红蛋白（18%）时，明显的缺氧心电图变化就会出现。这些模型表明，受损或超负荷的心脏对一氧化碳中毒的敏感性显著增加。
