Outpatient Department, Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing, China.
Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, 3/F, Building E12, Macao SAR, China; Center for Cognition and Brain Sciences, University of Macau, Macao SAR, China.
J Affect Disord. 2020 Oct 1;275:145-148. doi: 10.1016/j.jad.2020.06.033. Epub 2020 Jul 2.
High risk of mental health problems is associated with Coronavirus Disease 2019 (COVID-19). This study explored the prevalence of depressive symptoms (depression hereafter) and its relationship with quality of life (QOL) in clinically stable patients with COVID-19.
This was an online survey conducted in COVID-19 patients across five designated isolation hospitals for COVID-19 in Hubei province, China. Depression and QOL were assessed with standardized instruments.
A total of 770 participants were included. The prevalence of depression was 43.1% (95%CI: 39.6%-46.6%). Binary logistic regression analysis found that having a family member infected with COVID-19 (OR=1.51, P = 0.01), suffering from severe COVID-19 infection (OR=1.67, P = 0.03), male gender (OR=0.53, P<0.01), and frequent social media use to obtain COVID-19 related information (OR=0.65, P<0.01) were independently associated with depression. Patients with depression had lower QOL than those without.
Depression is highly prevalent in clinically stable patients with COVID-19. Regular screening and appropriate treatment of depression are urgently warranted for this population.
感染 2019 冠状病毒病（COVID-19）会带来较高的心理健康问题风险。本研究旨在探讨 COVID-19 临床稳定期患者抑郁症状（下文简称“抑郁”）的流行情况及其与生活质量（QOL）的关系。
本研究采用在线问卷调查的方式，对湖北省五所 COVID-19 指定隔离医院的 COVID-19 患者进行调查。使用标准化量表评估抑郁和 QOL。
共纳入 770 名患者。抑郁的患病率为 43.1%（95%CI：39.6%-46.6%）。二元逻辑回归分析发现，家庭成员感染 COVID-19（OR=1.51，P=0.01）、感染严重 COVID-19（OR=1.67，P=0.03）、男性（OR=0.53，P<0.01）和频繁使用社交媒体获取 COVID-19 相关信息（OR=0.65，P<0.01）与抑郁有关。患有抑郁的患者 QOL 低于无抑郁的患者。
COVID-19 临床稳定期患者的抑郁症状较为常见。该人群亟需定期进行抑郁筛查并给予适当的治疗。
