Department of Respiratory Diseases, University Hospital Gasthuisberg, Leuven, Belgium.
Am J Transplant. 2020 Nov;20(11):3234-3238. doi: 10.1111/ajt.16212. Epub 2020 Aug 29.
Several case reports and small case series have been published on coronavirus disease 2019 infection after solid organ transplantation; however, thus far there are limited data on coronavirus disease 2019 infections in lung transplant patients. In the present single-center case series we discuss 10 lung transplant patients with a documented severe acute respiratory syndrome coronavirus 2 infection, diagnosed with nasopharyngeal swab in 8 and bronchoalveolar lavage in 2. Eight of 10 patients needed hospital admission, of whom 1 was in the intensive care unit. He died after 2 weeks from multiple organ failure. The remaining nine patients recovered. Cell cycle inhibitors were withheld in all patients, whereas the calcineurin inhibitor and corticosteroids were continued at the same dose, with an acceptable outcome.
已经有几篇关于 2019 冠状病毒病（COVID-19）感染的个案报告和小病例系列发表在实体器官移植后；然而，迄今为止，关于肺移植患者的 COVID-19 感染的数据有限。在本单中心病例系列中，我们讨论了 10 例经证实的严重急性呼吸综合征冠状病毒 2 感染的肺移植患者，8 例通过鼻咽拭子和 2 例通过支气管肺泡灌洗诊断。10 例患者中有 8 例需要住院治疗，其中 1 例在重症监护病房。他因多器官衰竭在 2 周后死亡。其余 9 例患者康复。所有患者均停用细胞周期抑制剂，而钙调神经磷酸酶抑制剂和皮质类固醇继续以相同剂量使用，结果可接受。
