Wang W J, Gao Y H
Department of Hepatology, the First Hospital of Jilin University, Changchun 130021, China.
Zhonghua Gan Zang Bing Za Zhi. 2020 Jun 20;28(6):475-478. doi: 10.3760/cma.j.cn501113-20200311-00198.
Acetaldehyde dehydrogenase 2 (ALDH2) is a key enzyme in liver acetaldehyde metabolism (product of ethanol metabolism). Globally, about 8% of the population and about 30% to 40% of the East Asian population carry defective genes that encode no / low activity ALDH2. Recently, many studies have focused on the relationship between ALDH and viral hepatitis, alcoholic liver disease, liver fibrosis and liver cancer. Importantly, ALDH2 expression is closely related to the risk, pathogenesis and prognosis of liver cancer, so it can be used as a potential therapeutic target. This article summarizes and reviews the new progress and new research directions of this field.
乙醛脱氢酶2（ALDH2）是肝脏乙醛代谢（乙醇代谢产物）中的关键酶。在全球范围内，约8%的人口以及约30%至40%的东亚人口携带编码无/低活性ALDH2的缺陷基因。近年来，许多研究聚焦于ALDH与病毒性肝炎、酒精性肝病、肝纤维化和肝癌之间的关系。重要的是，ALDH2表达与肝癌的风险、发病机制及预后密切相关，因此它可作为一个潜在的治疗靶点。本文总结并综述了该领域的新进展和新研究方向。
