Winchester R, Brancato L, Itescu S, Skovron M L, Solomon G
Hospital for Joint Diseases, Department of Rheumatology, New York, NY 10003.
Scand J Rheumatol Suppl. 1988;74:89-93. doi: 10.3109/03009748809102943.
Information bearing on the prevalence and character of Reiter's syndrome and allied disorders as they occur in a setting of HIV infection was reviewed. Based on the frequency of infections by organisms capable of inducing reactive arthritis and the presence of HLA-B27 in 71% of the individuals, it was concluded that the disorder strongly resembled Reiter's syndrome occurring in the non-HIV infected group. Preliminary evidence suggested an enhanced penetrance of susceptibility among HLA-B27 individuals. In view of the preservation of CD8 lineage T cells and functional loss of CD4 lineage T cells in HIV-infected patients, it was suggested that a specific immune recognition event is at the center of the pathogenesis of this syndrome which involves preservation of an unknown antigen in the context of HLA-B27 to CD8 lineage suppressor/cytotoxic T cells.
对赖特综合征及相关疾病在HIV感染背景下的患病率和特征的相关信息进行了综述。基于能够诱发反应性关节炎的生物体感染频率以及71%的个体中存在HLA - B27，得出该疾病与非HIV感染组中发生的赖特综合征极为相似的结论。初步证据表明HLA - B27个体的易感性 penetrance增强。鉴于HIV感染患者中CD8谱系T细胞得以保留而CD4谱系T细胞功能丧失，有人提出特定的免疫识别事件是该综合征发病机制的核心，这涉及在HLA - B27背景下将一种未知抗原呈递给CD8谱系抑制性/细胞毒性T细胞。 （注：原文中“penetrance”这个词在医学语境下可能有特定含义，但仅按要求翻译，不太明确此处准确意思，暂保留英文未译）
