Department of Physical Therapy, Kyorin University, 5-4-1 Shimorenjaku, Mitaka, Tokyo, 181-8612, Japan.
Department of Occupational Therapy, Kyorin University, 5-4-1 Shimorenjaku, Mitaka, Tokyo, 181-8612, Japan.
J Physiol Sci. 2020 Jul 13;70(1):37. doi: 10.1186/s12576-020-00763-0.
Although anatomical studies have indicated pudendal motoneurons to give off recurrent collaterals, they are not considered to make synapses onto interneurons, such as Renshaw cells, and rather terminate their own signals. No study till date has examined interneurons being driven by recurrent collaterals of pudendal motoneurons. Here, we aimed to investigate the existence of Renshaw cells driven by pudendal motoneurons along with the recurrent inhibition of the latter. Extracellular recordings were obtained from the ventral horn of the sacral spinal cord of anesthetized cats. Dorsal roots were sectioned, and motor axons were electrically stimulated. Renshaw-like cells driven by recurrent collaterals, with high-frequency firings at short latency discharge, were observed around Onuf's nucleus. However, the recurrent inhibitory post-synaptic potentials were not recorded by intracellular recordings from the pudendal motoneurons. In summary, we found Renshaw-like cells driven by pudendal motoneurons, but we could not identify the synaptic connection of these neurons.
尽管解剖学研究表明阴部运动神经元会发出回返侧支，但它们不被认为会与中间神经元（如 Renshaw 细胞）形成突触，而是终止自身信号。迄今为止，尚无研究检查阴部运动神经元的回返侧支是否会驱动中间神经元。在这里，我们旨在研究阴部运动神经元的回返侧支是否会驱动 Renshaw 细胞，以及后者的回返抑制作用。在麻醉猫的骶髓腹角获得了细胞外记录。切断背根，用电刺激运动轴突。在 Onuf 核周围观察到由阴部运动神经元的回返侧支驱动的具有高频短潜伏期放电的 Renshaw 样细胞。然而，从阴部运动神经元的细胞内记录中未记录到回返性抑制性突触后电位。总之，我们发现了阴部运动神经元驱动的 Renshaw 样细胞，但无法确定这些神经元的突触连接。
