A contribution to mathematical modelling of immunological tolerance.

The original simple mathematical model describing the kinetics of B cell tolerance was extended by the inclusion of Th cell tolerance. It anticipates the existence of two compartments of B and Th cells reactive to the antigen--the immature cells and the mature ones. It is assumed that tolerance is induced by irreversible inactivation of the antigen-reactive cells and the escape from tolerance is due to their differentiation from the precursors. There is also considered the situation, where two categories of Th cells cooperate with the same B cells. Besides that, suppressive activity on Th cells is included in the model. The simulated values are compared with experimental data.