UGC Oftalmología, Hospital Universitario Virgen Macarena, Sevilla, España.
UGC Oftalmología, Hospital Universitario Virgen Macarena, Sevilla, España; Departamento de Cirugía, Universidad de Sevilla, Sevilla, España; RETICS-OFTARED.
Arch Soc Esp Oftalmol (Engl Ed). 2020 Nov;95(11):565-568. doi: 10.1016/j.oftal.2020.04.023. Epub 2020 Jul 11.
Seven patients (14 eyes) diagnosed with X-linked ichthyosis were studied using the Schirmer test, biomicroscopy, tonometry, endothelial count, optical coherence tomography, Pentacam®, ocular surface analyser, and confocal microscopy. The mean age was 33.83±20.17 years (range: 7-64 years). The most frequent findings in biomicroscopy were Meibomian glands dysfunction (83.3%) and stromal corneal opacities (33%). The tear break-up time was found shortened in 25% of the eyes. Confocal microscopy (both eyes) revealed activated keratocytes with hyper-reflective particles inside them in the anterior stroma and outside them in the posterior stroma. It is believed that the inclusion of the use of confocal microscopy will help in a better understanding of the corneal pathology associated with ichthyosis X, as well as new characteristics of these patients.
对 7 名（14 只眼）被诊断为 X 连锁鱼鳞癣的患者进行了 Schirmer 测试、生物显微镜检查、眼压测量、内皮细胞计数、光学相干断层扫描、Pentacam®、眼表面分析器和共焦显微镜检查。平均年龄为 33.83±20.17 岁（范围：7-64 岁）。生物显微镜检查最常见的发现是睑板腺功能障碍（83.3%）和基质角膜混浊（33%）。发现 25%的眼的泪膜破裂时间缩短。共焦显微镜（双眼）在前基质中发现了被激活的角膜细胞，其中有高反射颗粒，在后基质中发现了这些颗粒的外部。人们相信，共焦显微镜的使用将有助于更好地理解与 X 连锁鱼鳞癣相关的角膜病理学，以及这些患者的新特征。
