• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

自体淋巴细胞疗法:既往经验与未来展望。

Autolymphocyte therapy: previous experience and future prospects.

作者信息

Osband M E, Krane R J

机构信息

Joint Clinical Immunotherapy Program, Boston University School of Medicine, Mass.

出版信息

Pathol Immunopathol Res. 1988;7(6):483-93. doi: 10.1159/000157077.

DOI:10.1159/000157077
PMID:3266331
Abstract

Autolymphocyte therapy is outpatient medical treatment for selected patients, in which a relatively small amount of white blood cells is removed temporarily from the patients, modified in the laboratory through sophisticated biotechnology, and returned to the patient for the purpose of enhancing the immune system and contributing to improved health. We suggest that autolymphocyte therapy might be a useful approach in the prevention or treatment of several diseases. Previous work with autolymphocyte therapy in the treatment of metastatic renal cell carcinoma has demonstrated that this approach is minimally toxic and biologically active. Further clinical trials are justified and currently taking place.

摘要

自体淋巴细胞疗法是针对特定患者的门诊治疗方法,即从患者体内暂时取出相对少量的白细胞,在实验室通过先进的生物技术进行处理,然后再回输到患者体内,以增强免疫系统并促进健康改善。我们认为自体淋巴细胞疗法可能是预防或治疗多种疾病的一种有效方法。先前使用自体淋巴细胞疗法治疗转移性肾细胞癌的研究表明,这种方法毒性极小且具有生物活性。进一步的临床试验是合理的,并且正在进行中。

相似文献

1
Autolymphocyte therapy: previous experience and future prospects.自体淋巴细胞疗法:既往经验与未来展望。
Pathol Immunopathol Res. 1988;7(6):483-93. doi: 10.1159/000157077.
2
Treatment of metastatic renal cell carcinoma with autolymphocyte therapy. Low toxicity outpatient approach to adoptive immunotherapy without use of in vivo interleukin-2.采用自体淋巴细胞疗法治疗转移性肾细胞癌。采用低毒性门诊治疗方法进行过继性免疫治疗,不使用体内白细胞介素-2。
Urology. 1990 May;35(5):417-22. doi: 10.1016/0090-4295(90)80084-z.
3
Lymphocyte therapy of renal cell carcinoma.肾细胞癌的淋巴细胞疗法。
Expert Rev Anticancer Ther. 2005 Dec;5(6):1041-51. doi: 10.1586/14737140.5.6.1041.
4
Autolymphocyte therapy for metastatic renal cell carcinoma: initial clinical results from 335 patients treated in a multisite clinical practice.转移性肾细胞癌的自体淋巴细胞疗法:多中心临床实践中335例患者的初步临床结果
Transplant Proc. 1992 Dec;24(6):3059-64.
5
Autolymphocyte therapy in the treatment of metastatic renal cell carcinoma.自体外周血淋巴细胞疗法治疗转移性肾细胞癌
Urol Clin North Am. 1993 May;20(2):297-301.
6
Preparation for a phase I/II study using autologous gene modified T lymphocytes for treatment of metastatic renal cancer patients.使用自体基因修饰T淋巴细胞治疗转移性肾癌患者的I/II期研究的准备工作。
Adv Exp Med Biol. 1998;451:547-55. doi: 10.1007/978-1-4615-5357-1_85.
7
Effect of autolymphocyte therapy on survival and quality of life in patients with metastatic renal-cell carcinoma.自体淋巴细胞疗法对转移性肾细胞癌患者生存率和生活质量的影响。
Lancet. 1990 Apr 28;335(8696):994-8. doi: 10.1016/0140-6736(90)91064-h.
8
Implementation of an effective program for quality assurance and quality control in living cell therapy: a 2-year experience with autolymphocyte therapy.实施活细胞疗法质量保证和质量控制的有效方案:自体淋巴细胞疗法的两年经验
Transplant Proc. 1992 Dec;24(6):2803-8.
9
Feasibility and safety of adoptive immunotherapy with ex vivo-generated autologous, cytotoxic T lymphocytes in patients with solid tumor.采用体外生成的自体细胞毒性 T 淋巴细胞进行过继免疫疗法治疗实体瘤患者的可行性和安全性。
Cytotherapy. 2012 Jan;14(1):80-90. doi: 10.3109/14653249.2011.610303. Epub 2011 Sep 23.
10
The scientific and clinical results of ex vivo activated T cells for metastatic renal cell carcinoma in over 500 human patients.500多名人类患者中,用于转移性肾细胞癌的体外激活T细胞的科学和临床结果。
Cell Transplant. 1994;3 Suppl 1:S51. doi: 10.1177/096368979400301s18.