Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Center , Lahore, Pakistan.
Department of Cancer Registry and Clinical Data Management, Shaukat Khanum Memorial Cancer Hospital and Research Center , Lahore, Pakistan.
Expert Rev Respir Med. 2020 Nov;14(11):1173-1181. doi: 10.1080/17476348.2020.1796642. Epub 2020 Aug 14.
Airway stenting is an efficacious approach in management of malignant airway disease (MAD) with improvement in survival outcome.
To determine the indications and long-term clinical outcomes of tracheobronchial stenting in patients with MAD.
A cross-sectional review of 51 patients who underwent airway stenting from June 2011 to June 2019 was done. Paired t-test was used to compare mean difference of clinical characteristics between pre- and post-airway stenting. Kaplan-Meier curves were used to assess overall survival.
A total of 51 patients had stent insertion with mean age 46.63±17.10years including 27(52.9%) females. Mainly 37(72.5%) patients had esophageal and 06(11.8%) had lung cancer. The main indications were bronchial stenosis 18(35.3%), tracheal stenosis 11(21.6%) and Tracheo-esophageal/bronchial fistula 13(25.5%). Obstruction was intrinsic, extrinsic and mixed in 20(39.2%), 13(25.5%) and 5(9.8%) patients, respectively. There was statistically significant mean difference in pre- and post-procedure oxygen saturation (mean (M)=89.8, standard deviation (SD)=6.70 vs M =95.5,SD=2.54.p =0.001) and performance status (M =3.65,SD =0.6 vs M =2.59, SD=0.83.p =0.001). Overall median survival was 16±3.44 weeks, highest amongst patients with intrinsic obstruction (27±6.51 weeks).
Airway stenting is an effective endoscopic procedure to re-establish airway patency in MAD with minimal complications..
气道支架置入术在改善生存结果方面是恶性气道疾病（MAD）管理的有效方法。
确定 MAD 患者行气管支气管支架置入的适应证和长期临床结果。
对 2011 年 6 月至 2019 年 6 月期间行气道支架置入术的 51 例患者进行了横断面回顾性研究。采用配对 t 检验比较气道支架置入前后临床特征的均值差异。采用 Kaplan-Meier 曲线评估总生存率。
共 51 例患者行支架置入术，平均年龄 46.63±17.10 岁，其中 27 例（52.9%）为女性。主要为 37 例（72.5%）食管癌和 06 例（11.8%）肺癌。主要适应证为支气管狭窄 18 例（35.3%）、气管狭窄 11 例（21.6%）和气管-食管/支气管瘘 13 例（25.5%）。阻塞为内在性、外在性和混合性，分别为 20 例（39.2%）、13 例（25.5%）和 5 例（9.8%）。术前和术后血氧饱和度的平均（M）差异具有统计学意义（M=89.8，标准差（SD）=6.70 与 M=95.5，SD=2.54，p=0.001）和行为状态（M=3.65，SD=0.6 与 M=2.59，SD=0.83，p=0.001）。总中位生存时间为 16±3.44 周，内在性梗阻患者最高（27±6.51 周）。
气道支架置入术是一种有效的内镜手术，可重建 MAD 的气道通畅性，并发症少。
