原发性年龄相关性 tau 病（PART）：解决衰老大脑中神经元 tau 病变化的谱。
Primary Age-Related Tauopathy (PART): Addressing the Spectrum of Neuronal Tauopathic Changes in the Aging Brain.
机构信息
Department of Pathology and Cell Biology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, PH 15-124, New York, NY, 10032, USA.
Departments of Neurology, Pathology and Psychiatry, Center for Cognitive Neurology, NYU School of Medicine, Science Building, Rm 1017, 435 East 30th Street, New York, NY, 10016, USA.
出版信息
Curr Neurol Neurosci Rep. 2020 Jul 14;20(9):39. doi: 10.1007/s11910-020-01063-1.
Abstract
PURPOSE OF REVIEW
Primary age-related tauopathy (PART) was recently proposed as a pathologic diagnosis for brains that harbor neurofibrillary tangles (Braak stage ≤ 4) with little, if any, amyloid burden. We sought to review the clinicopathologic findings related to PART.
RECENT FINDINGS
Most adult human brains show at least focal tauopathic changes, and the majority of individuals with PART do not progress to dementia. Older age and cognitive impairment correlate with increased Braak stage, and multivariate analyses suggest that the rate of cognitive decline is less than matched patients with Alzheimer disease (AD). It remains unclear whether PART is a distinct tauopathic entity separate from AD or rather represents an earlier histologic stage of AD. Cognitive decline in PART is usually milder than AD and correlates with tauopathic burden. Biomarker and ligand-based radiologic studies will be important to define PART antemortem and prospectively follow its natural history.
摘要
目的综述
最近提出了原发性年龄相关性 tau 病（PART）作为一种病理学诊断，用于诊断具有神经纤维缠结（Braak 分期≤4）但淀粉样蛋白负担很少（如果有的话）的大脑。我们试图回顾与 PART 相关的临床病理发现。
最新发现
大多数成人的大脑至少显示出局灶性 tau 病改变，大多数 PART 患者不会进展为痴呆。年龄较大和认知障碍与 Braak 分期增加相关，多变量分析表明，认知下降的速度低于匹配的阿尔茨海默病（AD）患者。目前尚不清楚 PART 是否是一种与 AD 不同的 tau 病实体，还是代表 AD 的更早组织学阶段。PART 的认知下降通常比 AD 轻，与 tau 病负担相关。生物标志物和配体为基础的放射学研究对于 PART 的生前定义和前瞻性随访其自然史将非常重要。
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