School of Nursing, University of Alabama at Birmingham, AL, USA.
3463University of Florida, Gainesville, FL, USA.
Biol Res Nurs. 2020 Oct;22(4):458-471. doi: 10.1177/1099800420941105. Epub 2020 Jul 15.
Chronic pain is a significant public health problem in the United States, affecting approximately 100 million people. Yet there is a lack of robust biomarkers for clinical use in chronic pain conditions. Downstream effects of environmental, genomic, and proteomic variations in individuals with chronic pain conditions can be identified and quantified using a metabolomic approach.
AIM/DESIGN: The purpose of this systematic review was to examine the literature for reports of potential metabolomic signatures associated with chronic pain conditions.
We searched relevant electronic databases for published studies that used various metabolomic approaches to investigate chronic pain conditions among subjects of all ages.
Our search identified a total of 586 articles, 18 of which are included in this review. The reviewed studies used metabolomics to investigate fibromyalgia ( = 5), osteoarthritis ( = 4), migraine ( = 3), musculoskeletal pain ( = 2), and other chronic pain conditions ( = 1/condition). Results show that several known and newly identified metabolites differ in individuals with chronic pain conditions compared to those without these conditions. These include amino acids (e.g., glutamine, serine, and phenylalanine) and intermediate products (e.g., succinate, citrate, acetylcarnitine, and N-acetylornithine) of pathways that metabolize various macromolecules.
Though more high-quality research is needed, this review provides insights into potential biomarkers for future metabolomics studies in people with chronic pain conditions.
慢性疼痛是美国一个重大的公共健康问题，影响约 1 亿人。然而，在慢性疼痛状况下，临床应用的稳健生物标志物仍然缺乏。通过代谢组学方法，可以识别和量化慢性疼痛状况个体中环境、基因组和蛋白质组变异的下游效应。
目的/设计：本系统评价的目的是检查文献中与慢性疼痛状况相关的潜在代谢组学特征的报告。
我们搜索了相关的电子数据库，以寻找使用各种代谢组学方法研究各种年龄段的慢性疼痛状况的已发表研究。
我们的搜索共确定了 586 篇文章，其中 18 篇包含在本次综述中。综述研究使用代谢组学研究纤维肌痛（=5）、骨关节炎（=4）、偏头痛（=3）、肌肉骨骼疼痛（=2）和其他慢性疼痛状况（=1/状况）。结果表明，与没有这些状况的个体相比，患有慢性疼痛状况的个体中存在几种已知和新鉴定的代谢物差异。这些代谢物包括氨基酸（例如谷氨酰胺、丝氨酸和苯丙氨酸）和代谢各种大分子的途径的中间产物（例如琥珀酸、柠檬酸、乙酰肉碱和 N-乙酰鸟氨酸）。
尽管需要更多高质量的研究，但本综述为未来慢性疼痛状况人群的代谢组学研究提供了潜在生物标志物的见解。
