Barbieri P, Ciompi M L, Menicucci A, Pasero G
Department of Rheumatology, University of Pisa, Italy.
Clin Rheumatol. 1988 Dec;7(4):470-3.
Forty-four patients with typical palindromic rheumatism were typed for HLA-A,B,C and DR antigens. The mean duration of follow-up of our patients was 4.0 yrs. (range 1-12 yrs.). During this time 27% of patients showed a seropositivity; 22% of patients developed polyarthritis, 1 patient revealed a Sjögren syndrome and 3 patients showed a spontaneous improvement. The HLA-B16 antigen was increased in patients compared with controls, but the difference was not statistically significant. A, C and other B antigens were found with normal frequencies. The HLA-DR antigens did not reveal any differences between patients' and controls' values, either 40% of patients who developed RA carried the HLA DR4 antigen.
对44例典型回纹型风湿症患者进行了HLA - A、B、C和DR抗原分型。我们患者的平均随访时间为4.0年（范围1 - 12年）。在此期间，27%的患者出现血清阳性；22%的患者发展为多关节炎，1例患者出现干燥综合征，3例患者自发改善。与对照组相比，患者中HLA - B16抗原有所增加，但差异无统计学意义。A、C和其他B抗原的频率正常。HLA - DR抗原在患者和对照组的值之间未显示出任何差异，40%发展为类风湿关节炎的患者携带HLA DR4抗原。
