Departamento de Medicina Intensiva, Hospital Universitario Marqués de Valdecilla, Santander, Espanha.
Departamento de Anestesiologia e Reanimação, Hospital Universitario La Fé, Valencia, Espanha.
Rev Bras Ter Intensiva. 2020 Jun;32(2):277-283. doi: 10.5935/0103-507x.20200044. Epub 2020 Jul 13.
To determine micafungin plasma levels and pharmacokinetic behavior in patients treated with extracorporeal membrane oxygenation.
The samples were taken through an access point before and after the membrane in two tertiary hospitals in Spain. The times for the calculation of pharmacokinetic curves were before the administration of the drug and 1, 3, 5, 8, 18 and 24 hours after the beginning of the infusion on days one and four. The area under the curve, drug clearance, volume of distribution and plasma half-life time with a noncompartmental pharmacokinetic data analysis were calculated.
The pharmacokinetics of the values analyzed on the first and fourth day of treatment did not show any concentration difference between the samples taken before the membrane (Cin) and those taken after the membrane (Cout), and the pharmacokinetic behavior was similar with different organ failures. The area under the curve (AUC) before the membrane on day 1 was 62.1 (95%CI 52.8 - 73.4) and the AUC after the membrane on this day was 63.4 (95%CI 52.4 - 76.7), p = 0.625. The AUC before the membrane on day 4 was 102.4 (95%CI 84.7 - 142.8) and the AUC was 100.9 (95%CI 78.2 - 138.8), p = 0.843.
The pharmacokinetic parameters of micafungin were not significantly altered.
确定体外膜氧合治疗患者的米卡芬净血浆水平和药代动力学行为。
在西班牙的两家三级医院，通过一个接入点在膜前和膜后采集样本。计算药代动力学曲线的时间是在药物给药前，以及在输注开始后的第 1 天和第 4 天的 1、3、5、8、18 和 24 小时。采用非房室药代动力学数据分析计算曲线下面积、药物清除率、分布容积和血浆半衰期。
在治疗的第 1 天和第 4 天分析的药代动力学值，在膜前（Cin）和膜后（Cout）采集的样本之间没有显示出任何浓度差异，并且在不同器官衰竭时的药代动力学行为相似。第 1 天膜前的曲线下面积（AUC）为 62.1（95%CI 52.8-73.4），这天膜后的 AUC 为 63.4（95%CI 52.4-76.7），p=0.625。第 4 天膜前的 AUC 为 102.4（95%CI 84.7-142.8），而 AUC 为 100.9（95%CI 78.2-138.8），p=0.843。
米卡芬净的药代动力学参数没有明显改变。
