Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco (UPV/EHU), Manuel de Lardizabal 3, 20018, San Sebastián, Spain.
Chemistry. 2021 Jan 4;27(1):20-29. doi: 10.1002/chem.202002637. Epub 2020 Oct 29.
N,N-Diacylaminals are flexible molecular scaffolds that have commonly been utilized as amide surrogates in peptidomimetics. The singularities of this motif as an N-acyl imine equivalent and as hydrogen-bond donor have recently opened new synthetic opportunities, especially in the field of asymmetric catalysis. This concept article highlights this diverse synthetic potential and provides the elements necessary for further developments.
N,N-二酰亚胺是一种灵活的分子骨架，通常被用作肽模拟物中的酰胺替代物。这种结构作为 N-酰亚胺等价物和氢键供体的独特性最近为新的合成机会开辟了道路，特别是在不对称催化领域。本文重点介绍了这种多样化的合成潜力，并提供了进一步发展所需的要素。
