Department of General Surgery, The Third Hospital of Mianyang, Sichuan Mental Health Center, Mianyang 621000, Sichuan, China.
Aging (Albany NY). 2020 Jul 15;12(14):14271-14284. doi: 10.18632/aging.103457.
Claudin 18 (CLDN18) is a transmembrane protein that localizes to apical regions to form tight junction complexes. Abnormal expression of has been reported in gastric cancer (GC). The expression, genetic alterations, and prognostic role of were analyzed using public data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Human Protein Atlas (HPA) databases using multiple online tools. The biological network of was determined using GeneMANIA. Expression of was restricted to lung and stomach in normal tissues, was significantly downregulated in GC, but was ectopically overexpressed in some other cancer types. There was no correlation between mRNA expression of and the clinicopathology of GC, although expression was higher in the Epstein-Barr virus (EBV)-positive subgroup than other subgroups. Genetic alteration of was not a common event in GC; the main alteration was gene fusion with . expression did not predict the overall survival (OS) of GC patients. This study summarizes the expression features of in GC and suggests it may serve as a biomarker and therapy target for GC.
Claudin 18 (CLDN18) 是一种跨膜蛋白，位于细胞顶区，形成紧密连接复合物。已有研究报道 Claudin 18 在胃癌 (GC) 中异常表达。本研究利用 The Cancer Genome Atlas (TCGA)、Gene Expression Omnibus (GEO) 和 Human Protein Atlas (HPA) 数据库中的公共数据，并借助多个在线工具，分析 Claudin 18 的表达、遗传改变及其在 GC 中的预后作用。使用 GeneMANIA 确定 Claudin 18 的生物网络。在正常组织中 Claudin 18 仅在肺和胃中表达，在 GC 中显著下调，但在某些其他癌症类型中异位过表达。Claudin 18 的 mRNA 表达与 GC 的临床病理特征之间无相关性，尽管 EBV 阳性亚组的表达高于其他亚组。Claudin 18 的遗传改变在 GC 中并不常见，主要改变是与 基因融合。Claudin 18 的表达不能预测 GC 患者的总生存期 (OS)。本研究总结了 Claudin 18 在 GC 中的表达特征，提示其可能作为 GC 的生物标志物和治疗靶点。
