He Ting, Liao Zheng-Chang, Ding Ying, Wang Ming-Jie, Li Wen, Gan Ji-Min, Yue Shao-Jie
Department of Neonatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2020 Jul;22(7):684-689. doi: 10.7499/j.issn.1008-8830.2003276.
To compare the efficacy of domestic and imported caffeine citrate in the treatment of apnea in preterm infants.
A total of 98 preterm infants with a gestational age of 28 - <34 weeks between April 2018 and December 2019 were enrolled. They were randomly administered with domestic (n=48) or imported caffeine citrate (n=50) within 6 hours after birth. The therapeutic effects, complications, adverse effects and clinical outcomes were compared between the two groups.
There were no significant differences in the incidence of apnea within 7 days after birth, daily frequency of apnea, the time of apnea disappearance, the failure rate of intubation-surfactant-extubation strategy, the time of non-invasive assisted ventilation, the duration of oxygen therapy, the duration of caffeine citrate therapy, the length of hospital stay, blood gas analysis results, liver and kidney function testing results between the two groups (P>0.05). There were no significant differences in the incidence of complications and the mortality rate between the two groups (P>0.05). There was no significant difference in the incidence of adverse effects between the two groups (P>0.05).
The efficacy and safety of domestic caffeine citrate in the treatment of apnea are similar to those of imported caffeine citrate in preterm infants.
比较国产和进口枸橼酸咖啡因治疗早产儿呼吸暂停的疗效。
选取2018年4月至2019年12月期间98例胎龄为28 - ＜34周的早产儿。他们在出生后6小时内被随机给予国产枸橼酸咖啡因（n = 48）或进口枸橼酸咖啡因（n = 50）。比较两组的治疗效果、并发症、不良反应及临床结局。
两组在出生后7天内呼吸暂停发生率、每日呼吸暂停频率、呼吸暂停消失时间、插管-表面活性剂-拔管策略失败率、无创辅助通气时间、氧疗时间、枸橼酸咖啡因治疗时间、住院时间、血气分析结果、肝肾功能检测结果方面均无显著差异（P＞0.05）。两组并发症发生率和死亡率无显著差异（P＞0.05）。两组不良反应发生率无显著差异（P＞0.05）。
国产枸橼酸咖啡因治疗早产儿呼吸暂停的疗效和安全性与进口枸橼酸咖啡因相似。
