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改良 Corporoplasty 的长期手术、功能和患者报告结果:三级转诊中心经验。

Long-Term Surgical, Functional, and Patient Reported Outcomes of a Modified Corporoplasty: A Tertiary Referral Center Experience.

机构信息

Urology Clinic - A.O.U. "Città della Salute e della Scienza" - Molinette Hospital, University of Turin, Turin, Italy.

Urology Clinic - A.O.U. "Città della Salute e della Scienza" - Molinette Hospital, University of Turin, Turin, Italy.

出版信息

J Sex Med. 2020 Sep;17(9):1779-1786. doi: 10.1016/j.jsxm.2020.06.002. Epub 2020 Jul 12.

Abstract

BACKGROUND

Nesbit corporoplasty was proposed to address penile curvature (PC), both congenital (CPC) and acquired (APC).

AIM

To evaluate surgical, functional, and patient reported outcomes (PROs) of a modified corporoplasty.

METHODS

From May 2005 to January 2017, a consecutive series of patients underwent a modified corporoplasty. Data were retrospectively extrapolated. Intra and postoperative complications and hospital stay were recorded as surgical outcomes. 2 validated international questionnaires were administered preoperatively and at 12 months after surgery: International Index of Erectile Function and Sexual Encounter Profile (items 2-3). An "ad hoc" questionnaire was utilized to assess PROs.

OUTCOMES

Postoperative surgical and functional outcomes and PROs were the primary outcomes assessed in this study.

RESULTS

87 out of 145 patients had complete data available and were included in the study. CPC was noted in 61 patients whilst APC, secondary to Peyronie's disease, was present in 26 patients. Median preoperative PC was 60° (interquartile range [IQR] 45-70). Functional and PROs were evaluated 12 months after surgery for all enrolled patients. Considering surgical outcomes, the median follow-up time was 110 months (IQR 27-132.5). Median operative time was 130 minutes for CPC (IQR 115-150) and 120 minutes for APC (IQR 95-140). Median hospital stay was 2 days for both groups (IQR 1-2). After the median follow-up time of 110 months (IQR 27-132.5), a recurrent curvature was observed in 9.2% of cases. Minor residual curvature (<20°) was detected in 13.8%. International Index of Erectile Function and Sexual Encounter Profile 2-3 scores improved in both groups. Long-term de novo postoperative erectile dysfunction was observed in 3.2% of CPC cases and in 38.5% in APC (P = .001). A multivariate analysis revealed that etiology (APC), patient age (>35 years), and postoperative complications represented independent risk factors for the development of postoperative erectile dysfunction. Postoperative complications, in terms of bleeding, infection, or poor esthetic wound healing, occurred in 12.6% of patients. No Clavien-Dindo grade III-IV intraoperative complications were reported. Postoperative hematoma was more frequent in CPC when compared to APC (P = .003). In relation to PROs, 26.4% of patients responded as being dissatisfied with postoperative penile length, with a higher incidence in the APC group (P = .001). Overall, a significant improvement in everyday and sexual life quality was observed in both categories.

CLINICAL IMPLICATIONS

The modified corporoplasty described showed better residual curvature rates, whilst maintaining similar PROs even if APC patients reported less favorable outcomes when compared to CPC.

STRENGTHS & LIMITATIONS: The primary limitations of this study are its retrospective nature, no objective evaluation of postoperative curvature, and no penile length assessment.

CONCLUSION

The aforementioned corporoplasty may represent an excellent option for PC correction, with low complication rate and high patient satisfaction. Falcone M, CerutiC, Preto M, et al. Long-Term Surgical, Functional, and Patient Reported Outcomes of a Modified Corporoplasty: A Tertiary Referral Center Experience. J Sex Med 2020;17:1779-1786.

摘要

背景

Nesbit 阴茎海绵体白膜缩短术被提出用于治疗先天性(CPC)和获得性(APC)阴茎弯曲(PC)。

目的

评估改良阴茎海绵体白膜缩短术的手术、功能和患者报告的结局(PROs)。

方法

2005 年 5 月至 2017 年 1 月,连续一系列患者接受了改良阴茎海绵体白膜缩短术。回顾性提取数据。记录了术中术后并发症和住院时间作为手术结果。术前和术后 12 个月分别使用 2 种国际验证问卷:国际勃起功能指数和性体验问卷(项目 2-3)。使用“专门”问卷评估 PROs。

结果

87 例 CPC 和 26 例 APC 患者中有 87 例有完整数据,包括在研究中。CPC 患者 61 例,继发性 PC 患者 26 例,继发于 Peyronie 病。术前 PC 中位数为 60°(四分位距 [IQR] 45-70)。所有入组患者术后 12 个月评估功能和 PROs。考虑到手术结果,中位随访时间为 110 个月(IQR 27-132.5)。CPC 的中位手术时间为 130 分钟(IQR 115-150),APC 为 120 分钟(IQR 95-140)。两组中位住院时间均为 2 天(IQR 1-2)。在中位随访时间 110 个月(IQR 27-132.5)后,9.2%的病例出现复发性弯曲。13.8%的病例出现轻微残余弯曲(<20°)。两组的国际勃起功能指数和性体验问卷 2-3 评分均有所改善。CPC 中 3.2%的患者出现长期新发术后勃起功能障碍,APC 中 38.5%的患者出现勃起功能障碍(P=0.001)。多变量分析显示,病因(APC)、患者年龄(>35 岁)和术后并发症是术后勃起功能障碍发生的独立危险因素。12.6%的患者出现术后并发症,包括出血、感染或伤口愈合不良。无 Clavien-Dindo 分级 III-IV 术中并发症报告。与 APC 相比,CPC 术后血肿更常见(P=0.003)。关于 PROs,26.4%的患者对术后阴茎长度不满意,APC 组的发生率更高(P=0.001)。总体而言,两组患者的日常生活和性生活质量均有显著改善。

临床意义

描述的改良阴茎海绵体白膜缩短术显示出更好的残余弯曲率,同时保持相似的 PROs,即使 APC 患者的结果比 CPC 患者差。

优势与局限性

本研究的主要局限性是其回顾性、缺乏术后曲率的客观评估以及缺乏阴茎长度评估。

结论

上述阴茎海绵体白膜缩短术可能是治疗 PC 的一种极好的选择,并发症发生率低,患者满意度高。

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