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阿根廷患者复发型多发性硬化症的现有及新出现的治疗方法:综述

Current and emerging treatments for relapsing multiple sclerosis in Argentinian patients: a review.

作者信息

Rojas Juan I, Patrucco Liliana, Cristiano Edgardo

机构信息

Multiple Sclerosis Center of Buenos Aires, Neurology Department, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

出版信息

Degener Neurol Neuromuscul Dis. 2014 Jun 20;4:103-109. doi: 10.2147/DNND.S46557. eCollection 2014.

DOI:10.2147/DNND.S46557
PMID:32669904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7337150/
Abstract

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. Recent developments have led to newer therapeutic options for disease treatment. A few studies have reported MS prevalence rates between 12 and 20 per 100,000 inhabitants nationwide in Argentina, and an incidence of 1.76 cases per 100,000 inhabitants per year. Considering the epidemiology of MS in Argentina, the total number of patients affected is estimated at 5,000-8,000 patients, with nearly 55%-65% of patients having a relapsing-remitting MS subtype of the disease. The aim of this review is to provide an overview of current and emerging treatments available in Argentina for patients with MS.

摘要

多发性硬化症(MS)是一种中枢神经系统的自身免疫性疾病。最近的进展带来了用于疾病治疗的更新的治疗选择。一些研究报告称,在阿根廷全国范围内,MS的患病率为每10万居民中有12至20例,发病率为每年每10万居民中有1.76例。考虑到阿根廷MS的流行病学情况,估计受影响患者的总数为5000 - 8000名患者,其中近55% - 65%的患者患有复发缓解型MS亚型疾病。本综述的目的是概述阿根廷目前可用于MS患者的现有和新兴治疗方法。

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Degener Neurol Neuromuscul Dis. 2014 Jun 20;4:103-109. doi: 10.2147/DNND.S46557. eCollection 2014.
2
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引用本文的文献

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Biomedicines. 2018 Nov 30;6(4):112. doi: 10.3390/biomedicines6040112.
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Access and barriers to MS care in Latin America.拉丁美洲多发性硬化症护理的获取情况与障碍
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本文引用的文献

1
Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial.口服特立氟胺治疗复发型多发性硬化症(TOWER):一项随机、双盲、安慰剂对照的 3 期临床试验。
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[Multiple sclerosis in Argentina. Systematic review and meta-analysis].[阿根廷的多发性硬化症。系统评价与荟萃分析]
Medicina (B Aires). 2012;72(6):449-54.
3
The epidemiology of multiple sclerosis in Latin America and the Caribbean: a systematic review.拉丁美洲和加勒比地区多发性硬化症的流行病学:系统评价。
Mult Scler. 2013 Jun;19(7):844-54. doi: 10.1177/1352458512462918. Epub 2012 Oct 8.
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Risk of natalizumab-associated progressive multifocal leukoencephalopathy.纳武利尤单抗相关进行性多灶性白质脑病的风险。
N Engl J Med. 2012 May 17;366(20):1870-80. doi: 10.1056/NEJMoa1107829.
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Randomized trial of oral teriflunomide for relapsing multiple sclerosis.随机试验口服特立氟胺治疗复发型多发性硬化症。
N Engl J Med. 2011 Oct 6;365(14):1293-303. doi: 10.1056/NEJMoa1014656.
6
Differential effects of fingolimod (FTY720) on immune cells in the CSF and blood of patients with MS.芬戈莫德(FTY720)对 MS 患者脑脊液和血液中免疫细胞的差异影响。
Neurology. 2011 Apr 5;76(14):1214-21. doi: 10.1212/WNL.0b013e3182143564.
7
IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells.IL-27 通过抑制 Th17 细胞介导多发性硬化症患者对 IFN-β 治疗的反应。
Brain Behav Immun. 2011 Aug;25(6):1170-81. doi: 10.1016/j.bbi.2011.03.007. Epub 2011 Mar 21.
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Type I interferon inhibits interleukin-1 production and inflammasome activation.I 型干扰素抑制白细胞介素-1 的产生和炎症小体的激活。
Immunity. 2011 Feb 25;34(2):213-23. doi: 10.1016/j.immuni.2011.02.006.
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Glatiramer acetate treatment of multiple sclerosis: an immunological perspective.醋酸格拉替雷治疗多发性硬化症:免疫学视角
J Immunol. 2011 Feb 15;186(4):1887-90. doi: 10.4049/jimmunol.1090138.
10
Teriflunomide, an inhibitor of dihydroorotate dehydrogenase for the potential oral treatment of multiple sclerosis.特立氟胺,一种二氢乳清酸脱氢酶抑制剂,用于多发性硬化症的潜在口服治疗。
Curr Opin Investig Drugs. 2010 Nov;11(11):1313-23.