Medical Research Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.
Biological Resource Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, China.
Front Immunol. 2020 Jun 25;11:1349. doi: 10.3389/fimmu.2020.01349. eCollection 2020.
Human leukocyte antigen (HLA)-G, a non-classical HLA-class I molecule, has a low polymorphism frequency, restricted tissue distribution and immunoinhibitory property. HLA-G expression in tumor cells and cells chronically infected with virus may enable them to escape from host immune surveillance. It is well-known that the HLA-G molecule is a novel biomarker and potential therapeutic target that is relevant in various types of cancers, but its role in cervical cancer has not been fully explored. In this review, we aim to summarize and discuss the immunologic role of the HLA-G molecule in the context of HPV infections and the process of cervical cancer carcinogenesis. A better understanding of the potential impact of HLA-G on the clinical course of persistent HPV infections, cervical epithelial cell transformation, tumor growth, recurrence and metastasis is needed to identify a novel diagnostic/prognostic biomarker for cervical cancer, which is critical for cervical cancer risk screening. In addition, it is also necessary to identify HLA-G-driven immune mechanisms involved in the interactions between host and virus to explore novel immunotherapy strategies that target HLA-G/immunoglobulin-like transcript (ILT) immune checkpoints.
人类白细胞抗原（HLA）-G 是一种非经典的 HLA-I 类分子，具有低多态性频率、受限的组织分布和免疫抑制特性。肿瘤细胞和长期感染病毒的细胞中 HLA-G 的表达可能使它们能够逃避宿主的免疫监视。众所周知，HLA-G 分子是一种新型的生物标志物和潜在的治疗靶点，与各种类型的癌症有关，但它在宫颈癌中的作用尚未得到充分探索。在这篇综述中，我们旨在总结和讨论 HLA-G 分子在 HPV 感染和宫颈癌发生过程中的免疫作用。需要更好地了解 HLA-G 对持续性 HPV 感染、宫颈上皮细胞转化、肿瘤生长、复发和转移的临床过程的潜在影响，以确定宫颈癌的新型诊断/预后生物标志物，这对于宫颈癌风险筛查至关重要。此外，还需要确定 HLA-G 驱动的免疫机制在宿主与病毒相互作用中的作用，以探索针对 HLA-G/免疫球蛋白样转录物（ILT）免疫检查点的新型免疫治疗策略。
