Ito Yusuke, Takaoka Kensuke, Toyama Kazuhiro, Taoka Kazuki, Wakabayashi Yoshitaka, Shinozaki-Ushiku Aya, Okazaki Aiko, Chikamatsu Kinuyo, Mitarai Satoshi, Ushiku Tetsuo, Kurokawa Mineo
Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo.
Department of Infectious Diseases, The University of Tokyo Hospital.
Mediterr J Hematol Infect Dis. 2020 Jul 1;12(1):e2020035. doi: 10.4084/MJHID.2020.035. eCollection 2020.
This is the first case of concurrent lymphadenitis and Epstein-Barr virus (EBV)-positive lymphoproliferative disorder (LPD) in the same lymph node with no immunocompromised history. infection is a rare opportunistic infection mainly for human immunodeficiency virus (HIV)-infected patients. Although no immunodeficiency was detected in our patient, our case indicates that the immunodeficiency in the background of EBV latency type III and the immunosuppression by malignant lymphoma itself might induce the lymphadenitis. This case highly alerts clinicians to the immunosuppressive state of EBV-positive LPD with latency type III even if any immunodeficient serological factors are not detected.
这是首例在无免疫功能低下病史的同一淋巴结中并发淋巴结炎和爱泼斯坦-巴尔病毒（EBV）阳性淋巴增殖性疾病（LPD）的病例。感染是一种罕见的机会性感染，主要发生在人类免疫缺陷病毒（HIV）感染患者中。尽管在我们的患者中未检测到免疫缺陷，但我们的病例表明，EBV潜伏III型背景下的免疫缺陷以及恶性淋巴瘤本身的免疫抑制可能会诱发淋巴结炎。即使未检测到任何免疫缺陷血清学因素，该病例也高度警示临床医生注意潜伏III型EBV阳性LPD的免疫抑制状态。
