Abusharar Shady Piedra, Moku Prashanth, Banks Sharon, Khalid Fahad M, Specht Charles S, Polimera Hyma V
Penn State College of Medicine.
Penn State Hershey Medical Center, Hershey, PA, USA.
Clin Pract. 2020 Jun 30;10(2):1248. doi: 10.4081/cp.2020.1248. eCollection 2020 May 19.
Immune mediated necrotizing myopathy (IMNM) is part of the inflammatory myopathies group of diseases and presents with muscle weakness, myalgias and elevated serum creatine phosphokinase (CPK). Statin-induced IMNM is a rare complication. We present a patient with IMNM secondary to simvastatin use. The patient presented with proximal myopathy, dysphagia, and elevated creatinine kinase levels, and was subsequently found to have anti-3- hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies with a necrotizing process on muscle biopsy. This patient's case was further complicated by sequelae of multiple disease processes, ultimately leading to deterioration of his health.
免疫介导性坏死性肌病（IMNM）是炎性肌病疾病组的一部分，表现为肌肉无力、肌痛和血清肌酸磷酸激酶（CPK）升高。他汀类药物诱导的IMNM是一种罕见的并发症。我们报告一例继发于辛伐他汀使用的IMNM患者。该患者表现为近端肌病、吞咽困难和肌酐激酶水平升高，随后经肌肉活检发现有抗3-羟基-3-甲基戊二酰辅酶A还原酶（HMGCR）自身抗体以及坏死过程。该患者的病例因多种疾病过程的后遗症而进一步复杂化，最终导致其健康状况恶化。
