一项关于抗高血压药物对成年男性高血压患者性功能影响的前瞻性研究。

A prospective study of the effect of antihypertensive medications on the sexual functions of hypertensive adult male patients.

作者信息

Akinyede Akinwumi Akinyinka, Nwaiwu Obiyo, Fasipe Olumuyiwa John, Olusanya Adedunni, Olayemi Sunday Olufemi, Akande Bisola

机构信息

Department of Pharmacology, Therapeutics & Toxicology, Faculty of Basic Medical Sciences, University of Lagos, Idi-Araba, Lagos State, Nigeria.

Department of Clinical Pharmacology & Therapeutics, Faculty of Basic Clinical Sciences, University of Medical Sciences, Ondo City, Ondo State, Nigeria.

出版信息

Future Sci OA. 2020 Jun 2;6(6):FSO479. doi: 10.2144/fsoa-2020-0030.

DOI:10.2144/fsoa-2020-0030

PMID:32670607

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7351083/

Abstract

BACKGROUND

The potential for antihypertensive medications to produce deleterious adverse effects on sexual functions among hypertensive adult male patients has been widely reported, such adverse effects may limit drug adherence and compliance.

AIM

The aim of this study was to assess the effect of antihypertensive medication use on sexual functions among hypertensive adult male patients.

METHODOLOGY

The study was carried out at the outpatient clinic of a Nigerian University Teaching Hospital. A total of one hundred and fifty-nine recruited hypertensive adult male patients that were being managed at the center over a 3-month period between January 2017 and April 2017 participated in the study; provided they satisfied the inclusion and exclusion criteria for enrolment.

RESULTS

The respondents were between 30 and 98 years of age, (mean of 59 ± 11.1 years). Blood pressure recorded was during their initial medical diagnosis for hypertension. Systolic blood pressure recorded was between 128 and 194 mmHg (mean of 162 ± 16.4 mmHg), while their diastolic blood pressure was between 78 and 120 mmHg (mean of 95 ± 10.7 mmHg). The highest occurrence of sexual dysfunctions was associated with calcium-channel blockers in 32 (20.1%) patients, followed by diuretics in 27 (17.0%) and, angiotensin-converting enzyme inhibitors in 20 (12.6%) patients.

CONCLUSION

Calcium channel blockers caused the highest occurrence of sexual dysfunctions.

摘要

背景

抗高血压药物对成年男性高血压患者性功能产生有害副作用的可能性已被广泛报道，这些副作用可能会限制药物的依从性。

目的

本研究的目的是评估抗高血压药物的使用对成年男性高血压患者性功能的影响。

方法

该研究在尼日利亚一家大学教学医院的门诊进行。2017年1月至2017年4月期间，共有159名在该中心接受治疗达3个月的成年男性高血压患者参与了研究，前提是他们符合纳入和排除标准。

结果

受访者年龄在30至98岁之间，（平均年龄59±11.1岁）。记录的血压是他们最初诊断高血压时的血压。收缩压记录在128至194mmHg之间（平均162±16.4mmHg），而舒张压在78至120mmHg之间（平均95±10.7mmHg）。性功能障碍发生率最高的是32名（20.1%）使用钙通道阻滞剂的患者，其次是27名（17.0%）使用利尿剂的患者，以及20名（12.6%）使用血管紧张素转换酶抑制剂的患者。