Grundt Brian, Bolling Taryn, Ritch Mark L
Internal Medicine, University of South Florida Morsani College of Medicine, Largo Medical Center, Largo, USA.
Neurology, University of South Florida Morsani College of Medicine, Largo Medical Center, Largo, USA.
Cureus. 2020 Jun 10;12(6):e8546. doi: 10.7759/cureus.8546.
Reversible cerebral vasoconstriction syndrome (RCVS) is an under-diagnosed condition that results from reversible segmental and multifocal vasoconstriction of cerebral arteries. It can present with a variety of symptoms including sudden "thunder clap" headaches, neurologic deficits, photophobia, phonophobia, nausea, vomiting, and can mimic life-threatening conditions such as a ruptured intracranial aneurysm, primary angiitis of the central nervous system, and cervical artery dissection. The pathology of this condition is still not fully understood and the etiologies vary, making treatment difficult. Our objective is to draw attention to an under-diagnosed condition with common presenting symptoms. We present a 60-year-old male with sudden onset of severe headache, left-sided numbness and weakness, blurred vision, ataxia, nausea, and dyspnea. CT and MRI brain showed no evidence of infarct or hemorrhage. CT angiography (CTA) of the head and neck showed a narrow caliber basilar artery. With the patient's clinical presentation and imaging findings, RCVS was suspected and the patient was started on a calcium channel blocker and glucocorticoids. A repeat CTA of the head and neck was performed after initiation of therapy and showed dilation of the basilar artery. Treatment with verapamil and prednisone was continued and the patient's symptoms gradually improved. He was discharged to skilled nursing for continued physical therapy. RCVS is a little-understood, under-diagnosed condition that needs to be considered in patients presenting with headaches and neurologic deficits. Additionally, more research needs to be done to truly understand the etiology of this condition.
可逆性脑血管收缩综合征(RCVS)是一种诊断不足的疾病,由脑动脉可逆性节段性和多灶性血管收缩引起。它可表现为多种症状,包括突发的“霹雳样”头痛、神经功能缺损、畏光、畏声、恶心、呕吐,且可酷似危及生命的疾病,如颅内动脉瘤破裂、中枢神经系统原发性血管炎和颈动脉夹层。这种疾病的病理仍未完全明确,病因各异,导致治疗困难。我们的目的是引起对一种有常见症状但诊断不足的疾病的关注。我们报告一名60岁男性,突发严重头痛、左侧麻木和无力、视力模糊、共济失调、恶心和呼吸困难。头颅CT和MRI未显示梗死或出血迹象。头颈部CT血管造影(CTA)显示基底动脉管径变窄。根据患者的临床表现和影像学检查结果,怀疑为RCVS,遂开始给予患者钙通道阻滞剂和糖皮质激素治疗。治疗开始后再次进行头颈部CTA检查,显示基底动脉扩张。继续使用维拉帕米和泼尼松治疗,患者症状逐渐改善。他被转至专业护理机构继续接受物理治疗。RCVS是一种了解较少、诊断不足的疾病,对于出现头痛和神经功能缺损的患者需要考虑到这种疾病。此外,需要进行更多研究以真正了解这种疾病的病因。