Han Z C, Briere J, Parent D, Abgrall J F, Sensebe L
Department of Hematology, A. Morvan Hospital, Brest University School of Medicine, France.
J Biol Regul Homeost Agents. 1988 Jul-Sep;2(3):119-24.
Sera of patients with primary myelofibrosis (PMF), primary thrombocythemia (PT), polycythaemia vera (PV) and chronic myeloid leukemia (CML) contained a significantly increased F-CSA (or F-CSAs) compared to those of normal subjects and patients with secondary thrombocytosis (ST). This F-CSA was heat sensitive and had the capacity to promote both proliferation and maturation of normal marrow fibroblast colony-forming cells (CFU-F). This F-CSA seemed to be different from human platelet derived growth factor (PDGF), tumor necrosis factor (TNF) and fibroblast growth factor (FGF) from bovine brain. This F-CSA might be of importance in the pathogenesis of bone marrow fibrosis in myeloproliferative disorders.
与正常受试者及继发性血小板增多症（ST）患者相比，原发性骨髓纤维化（PMF）、原发性血小板增多症（PT）、真性红细胞增多症（PV）和慢性粒细胞白血病（CML）患者的血清中F-CSA（或F-CSAs）含量显著增加。这种F-CSA对热敏感，能够促进正常骨髓成纤维细胞集落形成细胞（CFU-F）的增殖和成熟。这种F-CSA似乎不同于人血小板衍生生长因子（PDGF）、肿瘤坏死因子（TNF）和牛脑成纤维细胞生长因子（FGF）。这种F-CSA可能在骨髓增殖性疾病的骨髓纤维化发病机制中具有重要作用。
