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水溶性两亲性钌(ii) 多吡啶配合物作为潜在的光激活治疗剂。

Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents.

机构信息

School of Chemistry and Trinity Biomedical Sciences Institute (TBSI), Trinity College Dublin, The University of Dublin, Dublin 2, Ireland.

出版信息

Chem Commun (Camb). 2020 Aug 21;56(65):9332-9335. doi: 10.1039/d0cc04397d. Epub 2020 Jul 16.

DOI:10.1039/d0cc04397d
PMID:32671364
Abstract

Two water-soluble amphiphilic Ru(ii) polypyridyl complexes containing N-1,10-phenanthrolin-5-yldocosanamide and 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ligands were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and displayed phototoxicity against HeLa cervical cancer cells.

摘要

两种水溶性两亲性 Ru(ii) 多吡啶配合物，分别含有 N-1,10-菲咯啉-5-基癸酰胺和 1,10-菲咯啉（phen）或 1,4,5,8-四氮杂菲（TAP）作为配体，被合成并评估了它们的光物理和光生物性质；这两种配合物都表现出快速的细胞摄取，并对 HeLa 宫颈癌细胞表现出光毒性。

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