Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, Jiangsu, China.
Dalton Trans. 2021 Mar 16;50(10):3536-3541. doi: 10.1039/d1dt00216c.
A well-designed heteroleptic ruthenium(ii) polypyridyl complex demonstrated stable target-specific in vitro Golgi apparatus imaging abilities in HeLa cell lines. After utilizing photodynamic therapy via UV excitation, the Ru-SL complex could be triggered to generate singlet oxygen (1O2) and red fluorescence signals. 1O2 was highly cytotoxic and could induce DNA damage and the disappearance of the Golgi apparatus. The red fluorescence signals disappeared gradually, suggesting that the live or dead state of the cells can be estimated from the fluorescence signal intensity.
设计良好的异双核钌（II）多吡啶配合物在 HeLa 细胞系中表现出稳定的靶向特异性高尔基体体外成像能力。通过 UV 激发进行光动力治疗后，Ru-SL 配合物可被触发产生单线态氧（1O2）和红色荧光信号。1O2 具有高细胞毒性，可诱导 DNA 损伤和高尔基体消失。红色荧光信号逐渐消失，表明可以根据荧光信号强度来估计细胞的死活状态。
