抗自噬药物的研究进展。

Progress of Anti-aging Drugs Targeting Autophagy.

机构信息

Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, 610065, Sichuan, China.

State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610065, Sichuan, China.

出版信息

Adv Exp Med Biol. 2020;1207:681-688. doi: 10.1007/978-981-15-4272-5_50.

DOI:10.1007/978-981-15-4272-5_50

PMID:32671785

Abstract

Senescence is a progressive process of degeneration that occurs when cells and organisms mature. Many studies have shown that autophagy is closely related to senescence. Autophagy gradually decreases with the senescence activity of cells, and vice versa. Therefore, moderate autophagy can protect the body and inhibit cell senescence. The inactivation of genes encoding nematode insulin-like tyrosine kinase receptor (daf-2) inhibited the activity of type I PI3K (age-1), Akt molecules (akt1, akt2), PDK (pdk-1), and TOR, and increased the lifespan and autophagy of Caenorhabditis elegans.

摘要

衰老（Senescence）是细胞和生物体成熟时发生的渐进性退化过程。许多研究表明，自噬与衰老密切相关。自噬随着细胞衰老活性的增加而逐渐减少，反之亦然。因此，适度的自噬可以保护身体并抑制细胞衰老。抑制编码线虫胰岛素样酪氨酸激酶受体（daf-2）的基因失活，会抑制 I 型 PI3K（age-1）、Akt 分子（akt1、akt2）、PDK（pdk-1）和 TOR 的活性，增加秀丽隐杆线虫的寿命和自噬。