Department of Internal Medicine, Division of Hematology/Oncology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, United States.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
BMB Rep. 2021 May;54(5):253-259. doi: 10.5483/BMBRep.2021.54.5.198.
Aging is characterized by a functional decline in most physiological processes, including alterations in cellular metabolism and defense mechanisms. Increasing evidence suggests that caloric restriction extends longevity and retards age-related diseases at least in part by reducing metabolic rate and oxidative stress in a variety of species, including yeast, worms, flies, and mice. Moreover, recent studies in invertebrates - worms and flies, highlight the intricate interrelation between reproductive longevity and somatic aging (known as disposable soma theory of aging), which appears to be conserved in vertebrates. This review is specifically focused on how the reproductive system modulates somatic aging and vice versa in genetic model systems. Since many signaling pathways governing the aging process are evolutionarily conserved, similar mechanisms may be involved in controlling soma and reproductive aging in vertebrates. [BMB Reports 2021; 54(5): 253-259].
衰老是大多数生理过程功能下降的特征，包括细胞代谢和防御机制的改变。越来越多的证据表明，热量限制通过降低各种物种（包括酵母、蠕虫、苍蝇和老鼠）的代谢率和氧化应激，至少在一定程度上延长了寿命并延缓了与年龄相关的疾病。此外，最近在无脊椎动物 - 蠕虫和苍蝇中的研究强调了生殖寿命和体衰老之间的复杂相互关系（称为衰老的可丢弃体细胞理论），这在脊椎动物中似乎是保守的。本综述特别关注生殖系统如何在遗传模型系统中调节体衰老，反之亦然。由于控制衰老过程的许多信号通路在进化上是保守的，因此类似的机制可能参与控制脊椎动物的体和生殖衰老。[BMB 报告 2021;54(5):253-259]。
