Department of Synthetic Chemistry and Biological Chemistry, Kyoto University, Katsura, Kyoto, 615-8510, Japan.
Angew Chem Int Ed Engl. 2020 Oct 5;59(41):18267-18271. doi: 10.1002/anie.202008897. Epub 2020 Aug 18.
A convenient method is reported to specifically acylate phenolic hydroxyl groups through a radical pathway. When a mixture of an aldehyde and a phenol in ethyl acetate is irradiated with blue light in the presence of iridium and nickel bromide catalysts at ambient temperature, phenoxyl and acyl radicals are transiently generated in situ and cross-couple to furnish an ester. Aliphatic hydroxy groups remain untouched under the reaction conditions.
一种方便的方法是通过自由基途径来特异性酰化酚羟基。当在室温下，在铱和溴化镍催化剂存在下，用蓝光照射乙酸乙酯中的醛和酚的混合物时，酚氧基和酰基自由基会在原位瞬时生成，并交叉偶联生成酯。在反应条件下，脂肪族羟基保持不变。
