Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003, United States.
Org Lett. 2020 Aug 7;22(15):5811-5816. doi: 10.1021/acs.orglett.0c01858. Epub 2020 Jul 16.
We report a diaryldiselenide catalyst for cross-dehydrogenative nucleophilic functionalization of hydrophosphoryl compounds. The proposed organocatalytic cycle closely resembles the mechanism of the Atherton-Todd reaction, with the catalyst serving as a recyclable analogue of the halogenating agent employed in the named reaction. Phosphorus and selenium NMR studies reveal the existence of a P-Se bond intermediate, and structural analyses indicate a stereospecific reaction.
我们报告了一种二芳基二硒化物催化剂，用于氢膦酰基化合物的交叉脱氢亲核官能化。所提出的有机催化循环与 Atherton-Todd 反应的机制非常相似，催化剂是所命名反应中所用卤化剂的可回收类似物。磷和硒 NMR 研究揭示了 P-Se 键中间体的存在，结构分析表明反应具有立体特异性。
