Behnke J, Mach J P, Buchegger F, Carrel S, Delaloye B, De Tribolet N
Neurosurgical Service, CHUV, Lausanne, Switzerland.
Br J Neurosurg. 1988;2(2):193-7. doi: 10.3109/02688698808992669.
F(ab')2-fragments of the anti-melanoma monoclonal antibody MeI-14 were labelled with 123I for external scanning and with 125I for tissue measurement of radioactivity and injected intravenously into patients scheduled for surgical resection of a glioma. The paired-label study was performed by injecting simultaneously 131I-labelled control (F(ab')2-fragments. The patients were scanned by computerised tomoscintigraphy. After surgery, the activities of 125I and 131I were counted in tumour and normal tissues. The results indicate that there was a low but definite uptake of the antibody in the tumour due to its specificity. The external detection was difficult because of accumulation of antibody fragments in the skull.
抗黑色素瘤单克隆抗体MeI-14的F(ab')2片段用123I标记用于外部扫描，用125I标记用于组织放射性测量，并静脉注射给计划进行神经胶质瘤手术切除的患者。通过同时注射131I标记的对照（F(ab')2片段）进行配对标记研究。患者通过计算机断层闪烁扫描进行扫描。手术后，在肿瘤组织和正常组织中对125I和131I的活性进行计数。结果表明，由于抗体的特异性，肿瘤中存在低但确定的摄取。由于抗体片段在颅骨中的积累，外部检测困难。
