Departamento de Medicina Interna, Universidad El Bosque, Bogotá, D.C., Colombia.
Departamento de Medicina Crítica y Cuidado Intensivo, Universidad del Rosario, Bogotá, D.C., Colombia.
Biomedica. 2020 Jun 15;40(2):228-232. doi: 10.7705/biomedica.5140.
Strongyloidiasis is a disease caused by the nematode Strongyloides stercoralis that is endemic in rural regions in tropical and subtropical countries. Immunosuppressed patients have an increased risk of infection by this parasite and are at risk of developing a hyperinfection syndrome which involves a higher risk of death. The syndrome is treated with ivermectin, however, there is no parenteral presentation of this medication for human use in Colombia or the world, which is an important problem in patients who have compromised enteral absorption, for instance, those with intestinal obstructions. We present a case of hyperinfection syndrome by Strongyloides stercoralis in Colombia, which was treated with subcutaneous ivermectin. Our purpose is to encourage pharmacokinetic and pharmacodynamic studies to establish this route of administration in the future as an alternative for those patients who have a high risk of therapeutic failure with the oral route.
粪类圆线虫病是一种由热带和亚热带国家农村地区流行的圆线虫属寄生虫引起的疾病。免疫抑制患者感染这种寄生虫的风险增加，并且有发展为过度感染综合征的风险，这涉及更高的死亡风险。该综合征用伊维菌素治疗，然而，在哥伦比亚或世界范围内，没有这种药物的肠外制剂用于人类，这对于那些肠内吸收受损的患者（例如，有肠道梗阻的患者）来说是一个重要问题。我们在哥伦比亚报告了一例由粪类圆线虫引起的过度感染综合征，该病例用皮下伊维菌素治疗。我们的目的是鼓励进行药代动力学和药效学研究，以便将来为那些经口服途径治疗失败风险高的患者建立这种给药途径作为替代方案。
