Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, CHE 202, Tampa, Fl 33620, United States.
J Org Chem. 2020 Aug 7;85(15):9928-9935. doi: 10.1021/acs.joc.0c01150. Epub 2020 Jul 26.
A family of three spatially directional resorcin[4]arene cavitand glycoconjugates () have been applied as efficient recoverable and reusable inverse phase transfer catalysts for eco- and environmentally friendly thiocyanation and 2-amino-1,3-thiazole formation reactions in water. The results show that (1 mol %) were capable of hosting and catalyzing various water-insoluble bromo/thiocyanato substrates in water without the use of any co-organic solvents. The recoverability and reusability of catalytic systems, that is, and , were also examined upon a simple extraction of the desired products using DCM or ethyl acetate, followed by subjecting the recovered aqueous solution containing the catalysts to the next reaction cycles.
已将三种具有空间定向性的间苯二酚[4]芳烃空腔配体糖缀合物（）家族应用于作为高效可回收和可重复使用的反相转移催化剂，用于在水中进行环保且环境友好的硫氰化和 2-氨基-1,3-噻唑形成反应。结果表明，（1 摩尔%）能够在水中容纳和催化各种不溶于水的溴代/硫氰酸酯底物，而无需使用任何有机溶剂。还通过使用 DCM 或乙酸乙酯简单萃取所需产物，然后将含有[催化剂]的回收水溶液进行下一个反应循环，对催化体系的可回收性和可重复使用性进行了考察。
