Department of Breast Surgery, Cancer Hospital of China Medical University, Shenyang, Liaoning Province, P.R. China.
Department of Bone Surgery, People's Hospital of Liaoning Province, Shenyang, Liaoning Province, P.R. China.
J Int Med Res. 2020 Jul;48(7):300060520937618. doi: 10.1177/0300060520937618.
The ataxia telangiectasia mutated () gene contains a functional single nucleotide polymorphism (SNP) rs1801516 (G > A) that may be associated with cancer risk. This meta-analysis aimed to interrogate the relationship between rs1801516 and cancer occurrence and disease etiology.
We retrieved and identified the available case-control studies that met the inclusion criteria from the PubMed, Web of Science, and Embase databases. Odds ratio (OR) and 95% confidence intervals (CIs) were used to measure the association between rs1801516 and cancer risk. Additionally, we performed sensitivity, subgroup, and publication bias analyses.
After inclusion criteria were met, the meta-analysis included 29 studies, with 9,453 cancer patients (cases) and 14,646 controls. No association was found between rs1801516 and cancer risk (pooled OR = 0.911; 95% CI, 0.740-1.123). Concordantly, no association was found between rs1801516 and cancer risk after subgroup analysis by source of controls, cancer type, or ethnicity, which confirmed the finding of the dominant model that this SNP is not involved in the occurrence of cancer.
Through this meta-analysis, we found no association between rs1801516 and cancer occurrence as a risk factor. These data provide useful information for future case-control studies on cancer etiology.
共济失调毛细血管扩张突变（）基因包含一个功能性的单核苷酸多态性（SNP）rs1801516（G>A），可能与癌症风险相关。本荟萃分析旨在探讨 rs1801516 与癌症发生和疾病病因的关系。
我们从 PubMed、Web of Science 和 Embase 数据库中检索并确定了符合纳入标准的可用病例对照研究。比值比（OR）和 95%置信区间（CI）用于衡量 rs1801516 与癌症风险之间的关联。此外，我们还进行了敏感性、亚组和发表偏倚分析。
符合纳入标准后，荟萃分析纳入了 29 项研究，共 9453 名癌症患者（病例）和 14646 名对照。rs1801516 与癌症风险之间没有关联（合并 OR=0.911；95%CI，0.740-1.123）。同样，在按对照来源、癌症类型或种族进行亚组分析后，也没有发现 rs1801516 与癌症风险之间的关联，这证实了该 SNP 不参与癌症发生的显性模型的发现。
通过这项荟萃分析，我们没有发现 rs1801516 与癌症发生作为危险因素之间的关联。这些数据为未来癌症病因学的病例对照研究提供了有用的信息。
