Comparative Medicine, Division of Laboratory Animal Resources, Medical University of South Carolina, Charleston, South Carolina; Pathology and Laboratory Medicine, Division of Laboratory Animal Resources, Medical University of South Carolina, Charleston, South Carolina;, Email:
Comparative Medicine, Division of Laboratory Animal Resources, Medical University of South Carolina, Charleston, South Carolina; Research Services, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina.
Comp Med. 2020 Aug 1;70(4):376-383. doi: 10.30802/AALAS-JAALAS-19-000162. Epub 2020 Jul 16.
Perioperative complications and deaths occurred while developing a novel surgical model of pediatric kyphosis in 10 to 12 kg male farm-raised Yorkshire piglets. All piglets appeared clinically normal preoperatively. Intraoperative complications included tachycardia, respiratory acidosis, and death. Postoperatively, clinical signs included posterior paresis, head pressing, prolonged anesthetic recovery, difficulty rising, and sudden death. Necropsies were performed on all piglets. Some morbidity and mortality were accurately attributed to the spinal surgery. However, the index piglet for this report died suddenly approximately 16 to 18 h after surgery. Necropsy of this animal revealed clear, serosanguineous pleural and pericardial effusions along with myocardial hemorrhage and hepatic lesions, consistent with mulberry heart disease and hepatosis dietetica, respectively. Serum vitamin E and selenium levels from this animal were below age-specific lab reference ranges. Clinical signs of vitamin E and selenium deficiency are most common in fast-growing weaner piglets. The added stress of major surgery may exacerbate the condition in young piglets. Resolution of morbidity and mortality in both juvenile and adult pigs occurred upon the use of an alternate vendor able to provide feed analyses meeting industry standards, although serum levels of vitamin E and selenium in similar ages and breed of swine were still occasionally slightly below reference ranges.
在建立一种新的儿科脊柱后凸手术模型的过程中，10 到 12 公斤重的雄性农场饲养约克夏仔猪出现了围手术期并发症和死亡。所有仔猪术前均表现为临床正常。术中并发症包括心动过速、呼吸性酸中毒和死亡。术后临床症状包括后肢瘫痪、头部按压、麻醉恢复时间延长、站立困难和突然死亡。所有仔猪均进行了尸检。一些发病率和死亡率可准确归因于脊柱手术。然而，本报告的指数仔猪在手术后约 16 至 18 小时突然死亡。该动物的尸检显示，伴有心肌出血和肝损伤的清晰、血性胸腔和心包积液，分别符合桑葚心和营养性肝病变。该动物的血清维生素 E 和硒水平低于特定年龄的实验室参考范围。快速生长的断奶仔猪最常见维生素 E 和硒缺乏的临床症状。大型手术的额外压力可能会使仔猪的病情恶化。在使用能够提供符合行业标准的饲料分析结果的替代供应商后，幼年和成年猪的发病率和死亡率均得到了缓解，尽管在类似年龄和品种的猪中，血清维生素 E 和硒水平仍偶尔略低于参考范围。
