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[用于慢性阻塞性肺疾病早期诊断的吸烟包年阈值及慢性阻塞性肺疾病自我调查问卷]

[Pack-years threshold and HAS self-questionnaire for COPD early diagnosis].

作者信息

Lorenzo M, Delpeyroux S, Dupre V

机构信息

Département de médecine générale, UFR de médecine, université de Strasbourg, Strasbourg, France; Maison de santé pluriprofessionnelle Guillaume Tell, 2, place Guillaume-Tell, 68100 Mulhouse, France.

Département de médecine générale, UFR de médecine, université de Strasbourg, Strasbourg, France.

出版信息

Rev Mal Respir. 2020 Oct;37(8):624-632. doi: 10.1016/j.rmr.2020.06.011. Epub 2020 Jul 14.

Abstract

INTRODUCTION

The Haute Autorité de santé (HAS) in France offers a patient self-questionnaire to optimize targeted chronic obstructive pulmonary disease (COPD) screening among at-risk patients in primary care. It includes smoking but does not have a threshold for pack-years (PY) smoked. The objective of this study was to compare the positive predictive values (PPV) of the HAS self-questionnaire alone and with the addition of a PY threshold.

METHODS

This was a prospective pilot study conducted in a multi-professional health centre. Identification among smoking or former smoking patients without a COPD diagnosis of subjects with a positive HAS self-questionnaire, a positive PY threshold, or both. We performed spirometry after bronchodilatation.

RESULTS

Thirty-five people were included in the study. All 35 had a positive PY threshold. The HAS questionnaire was positive for 22 of them (62.9%). Spirometry diagnosed 18 participants with COPD (51%). The PPV for the HAS questionnaire was 0.41 and the PPV for the HAS+PY questionnaire was 0.51. There was no statistically significant difference between these two PPVs (P=0.3692).

CONCLUSIONS

The addition of a PY threshold to the HAS self-questionnaire may allow better targeting of the population at risk of developing COPD.

摘要

引言

法国卫生高级管理局(HAS)提供了一份患者自我调查问卷,以优化基层医疗中高危患者的慢性阻塞性肺疾病(COPD)针对性筛查。该问卷包含吸烟情况,但未设定吸烟包年数(PY)的阈值。本研究的目的是比较仅使用HAS自我调查问卷与增加PY阈值后的阳性预测值(PPV)。

方法

这是一项在多专业健康中心进行的前瞻性试点研究。在未诊断出患有COPD的吸烟或既往吸烟患者中,识别出HAS自我调查问卷呈阳性、PY阈值呈阳性或两者均呈阳性的受试者。我们在支气管扩张后进行了肺功能测定。

结果

35人纳入研究。所有35人的PY阈值均为阳性。其中22人(62.9%)的HAS问卷呈阳性。肺功能测定诊断出18名参与者患有COPD(51%)。HAS问卷的PPV为0.41,HAS+PY问卷的PPV为0.51。这两个PPV之间无统计学显著差异(P=0.3692)。

结论

在HAS自我调查问卷中增加PY阈值可能会更好地针对有患COPD风险的人群。

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