Luley K, Gebauer J, Gebauer N, Tharun L, Buchmann I, Barkhausen J, von Bubnoff N, Lindner K, Keck T, Lehnert H, Schmid S M
Klinik für Hämatologie und Onkologie, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.
Med. Klinik 1, Abteilung für Endokrinologie, Diabetologie und Stoffwechselmedizin, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.
Internist (Berl). 2020 Aug;61(8):875-890. doi: 10.1007/s00108-020-00832-x.
The term neuroendocrine neoplasms (NEN) encompasses a molecularly and biologically very heterogeneous group of tumors, which have in common their origin in neuroendocrine cells. The also very heterogeneous subgroup of gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN) is the best classified and investigated group. This article provides a systematic review of the current classification, diagnostics and treatment options of GEP-NEN. In order to achieve a better overview, it was consciously decided not to use an approach based on the primary localization. Instead, a thematic organization according to classification, clinical phenotype, diagnostics and treatment was chosen.
神经内分泌肿瘤（NEN）这一术语涵盖了一组在分子和生物学上非常异质性的肿瘤，它们的共同之处在于起源于神经内分泌细胞。胃肠胰神经内分泌肿瘤（GEP-NEN）这一同样非常异质性的亚组是分类和研究得最好的组。本文对GEP-NEN的当前分类、诊断和治疗选择进行了系统综述。为了获得更好的概述，特意决定不采用基于原发部位的方法。相反，选择了根据分类、临床表型、诊断和治疗进行主题组织的方式。
