胃肠胰神经内分泌肿瘤的治疗

Treatment of Gastroenteropancreatic Neuroendocrine Tumors.

作者信息

Perez Kimberly, Chan Jennifer

机构信息

Program in Carcinoid and Neuroendocrine Tumors, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA.

出版信息

Surg Pathol Clin. 2019 Dec;12(4):1045-1053. doi: 10.1016/j.path.2019.08.011.

DOI:10.1016/j.path.2019.08.011

PMID:31672293

Abstract

Neuroendocrine tumors (NETs) represent a group of biologically and clinically heterogeneous neoplasms arising from the diffuse neuroendocrine system. Although NETs may develop in almost any organ, they commonly arise in the gastrointestinal tract and pancreas and are referred to as gastroenteropancreatic (GEP)-NETs when they arise from these sites. In recent years, advances in understanding of the biology of NETs have resulted in an expansion in treatment options and improved survival for patients. This review focuses on treatment of GEP-NETS and highlights factors that govern the therapeutic approach.

摘要

神经内分泌肿瘤（NETs）是一组起源于弥漫性神经内分泌系统的生物学和临床异质性肿瘤。尽管NETs几乎可在任何器官发生，但它们通常起源于胃肠道和胰腺，当起源于这些部位时被称为胃肠胰腺（GEP）-NETs。近年来，对NETs生物学认识的进展带来了治疗选择的增加和患者生存率的提高。本综述聚焦于GEP-NETs的治疗，并强调了指导治疗方法的因素。