骨髓活检初诊转移性结直肠癌 1 例并文献复习
Metastatic colorectal carcinoma initially diagnosed by bone marrow biopsy: a case report and literature review.
机构信息
Medical Oncology Department, Oncology Center, Mansoura University, Mansoura, Egypt.
Diagnostic Radiology Department, Mansoura University Hospitals, Mansoura, Egypt.
出版信息
J Egypt Natl Canc Inst. 2020 Jul 17;32(1):30. doi: 10.1186/s43046-020-00040-6.
BACKGROUND
Colorectal carcinoma still represents a global health burden despite the advances in its management. The most common sites of distant metastasis from colorectal carcinoma are hepatic and pulmonary metastases while metastases are rarely reported to affect the bone marrow.
CASE PRESENTATION
We report a 33-year-old female patient who presented with fever of unknown origin, bone aches limited to the lower back and pelvis, and pancytopenia. She was diagnosed by a bone marrow biopsy as a case of metastatic rectosigmoid carcinoma. Serum tumor markers were within normal ranges; CT, MRI, and colonoscopy confirmed the presence of malignant rectosigmoid mass with bone and ovarian metastases.
CONCLUSION
Though being rare, bone marrow metastasis should be suspected in colorectal carcinoma cases with abnormalities in peripheral blood count.
背景
尽管在结直肠癌的治疗方面取得了进展，但它仍然是全球健康的负担。结直肠癌最常见的远处转移部位是肝和肺转移，而骨髓转移则很少见。
病例介绍
我们报告了一名 33 岁女性患者，她以不明原因发热、仅限于下背部和骨盆的骨痛和全血细胞减少为特征。骨髓活检诊断为直肠乙状结肠转移癌。血清肿瘤标志物在正常范围内；CT、MRI 和结肠镜检查证实存在恶性直肠乙状结肠肿块，并伴有骨和卵巢转移。
结论
尽管罕见，但结直肠癌患者外周血象异常时应怀疑骨髓转移。
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