Itagane H, Hirota K, Teragaki M, Akioka K, Yasuda M, Oku H, Takeuchi K, Takeda T, Ochi H
First Department of Internal Medicine, Osaka City University Medical School.
J Cardiol. 1988 Dec;18(4):949-54.
Ga-67-DFO-DAS-fibrinogen (Ga-fbg) scintigraphy, a new radiopharmaceutical method, was performed for detecting intraventricular thrombi following acute myocardial infarction in five patients. The thrombi in four of them were detected by two-dimensional echocardiography (2DE) and that in the fifth patient was suspected during magnetic resonance imaging. Imaging of the heart was performed using a scinticamera with a medium energy collimator and multiple views (anterior, LAO 30 degrees, LAO 45 degrees, and lateral) three and four days after the intravenous administration of Ga-fbg. By Ga-fbg scintigraphy, intraventricular thrombi were detected in four patients. The size of the thrombi visualized by Ga-fbg appeared larger than those by 2DE. In one patient examined again after anticoagulant therapy, a thrombus was missed by 2-DE, but it was detected by Ga-fbg, though the radioactivity of the thrombus decreased. We concluded that Ga-fbg scintigraphy is a very simple method and sufficiently useful for detecting active left ventricular thrombi and for monitoring the effect of anticoagulant therapy. It could be more sensitive than 2DE for determining the extent of an active intraventricular thrombus.
镓-67-去铁胺-双乙酰半胱氨酸-纤维蛋白原（Ga-fbg）闪烁扫描术是一种新型放射性药物检测方法，用于检测5例急性心肌梗死后的心室内血栓形成情况。其中4例患者的心室内血栓通过二维超声心动图（2DE）检测到，第5例患者的血栓在磁共振成像检查时被怀疑存在。在静脉注射Ga-fbg后3天和4天，使用配备中能准直器的闪烁相机从多个角度（前位、左前斜30度、左前斜45度和侧位）对心脏进行成像。通过Ga-fbg闪烁扫描术，4例患者的心室内血栓被检测到。Ga-fbg显示的血栓大小似乎比2DE显示的更大。在1例接受抗凝治疗后再次检查的患者中，2DE未检测到血栓，但Ga-fbg检测到了，尽管血栓的放射性降低了。我们得出结论，Ga-fbg闪烁扫描术是一种非常简单的方法，对于检测活动性左心室血栓和监测抗凝治疗效果非常有用。在确定活动性心室内血栓的范围方面，它可能比2DE更敏感。
