Arch Argent Pediatr. 2020 Aug;118(4):S118-S129. doi: 10.5546/aap.2020.S118.
In recent decades, chronic non-communicable diseases (NCDs) have become the leading cause of global mortality and increased in Latin America. The contribution of the resources from development science, epigenetics, neurosciences, environmental sciences, epidemiology and research has generated evidence of the origin of NCDs since fetal programming. The health and disease outcomes result from a dynamic trajectory where protective factors are added for a healthy life or risk factors for diseases of the individual and the communities. Developmental Origins of Health and Disease concept resizes the role of the maternal and child health team and should guide public policies by prioritizing the first 1000 days of life for healthy development and NCDs prevention. We present an update on principal adverse environmental conditions that may alter development programming and predispose NCDs in life course.
近几十年来,慢性非传染性疾病(NCDs)已成为全球死亡的主要原因,且在拉丁美洲呈上升趋势。发育科学、表观遗传学、神经科学、环境科学、流行病学及研究等领域的资源贡献,已产生了自胎儿编程以来非传染性疾病起源的证据。健康和疾病结果源于一条动态轨迹,在这条轨迹上,为健康生活添加了保护因素,或者为个人及社区的疾病添加了风险因素。健康与疾病的发育起源概念重新界定了母婴健康团队的作用,应以优先考虑生命最初1000天的健康发育和非传染性疾病预防来指导公共政策。我们提供了一份关于可能改变发育编程并使人在生命历程中易患非传染性疾病的主要不利环境状况的最新情况。