Department of Pathology, University of Michigan Medical School, 7520 MSRB I, 1150 West Medical Center Dr, Ann Arbor, MI, 48109-5602, USA.
Graduate Program in Neuroscience, University of Michigan Medical School, Ann Arbor, MI, USA.
Fluids Barriers CNS. 2020 Jul 16;17(1):44. doi: 10.1186/s12987-020-00202-7.
The complexity of the blood-brain barrier (BBB) and neurovascular unit (NVU) was and still is a challenge to bridge. A highly selective, restrictive and dynamic barrier, formed at the interface of blood and brain, the BBB is a "gatekeeper" and guardian of brain homeostasis and it also acts as a "sensor" of pathological events in blood and brain. The majority of brain and cerebrovascular pathologies are associated with BBB dysfunction, where changes at the BBB can lead to or support disease development. Thus, an ultimate goal of BBB research is to develop competent and highly translational models to understand mechanisms of BBB/NVU pathology and enable discovery and development of therapeutic strategies to improve vascular health and for the efficient delivery of drugs. This review article focuses on the progress being made to model BBB injury in cerebrovascular diseases in vitro.
血脑屏障 (BBB) 和神经血管单元 (NVU) 的复杂性一直是一个难以跨越的挑战。BBB 是在血液和大脑的交界处形成的高度选择性、限制性和动态屏障，是大脑内环境稳定的“守门员”和守护者，也是血液和大脑中病理事件的“传感器”。大多数脑和脑血管疾病都与 BBB 功能障碍有关，BBB 的变化可导致或支持疾病的发展。因此，BBB 研究的最终目标是开发有能力且高度转化的模型，以了解 BBB/NVU 病理学的机制，并能够发现和开发改善血管健康和提高药物有效传递的治疗策略。本文综述了在体外模拟脑血管疾病 BBB 损伤方面的进展。
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