Emergency Department, CHU Besançon, 3 boulevard Alexandre Fleming, 25030, Besançon, France.
Laboratory Chrono-Environnement, UMR 6249 Centre National de la Recherche Scientifique, 16 route de Gray, 25000, Besançon, France.
Sci Rep. 2020 Jul 16;10(1):11823. doi: 10.1038/s41598-020-68831-4.
Secondary spontaneous pneumothorax (SSP) occurs in the context of underlying pulmonary disease. Our objectives were to estimate the relationship between SSP and short term air pollution exposure with nitrogen dioxide (NO), ozone (O) and particulate matter with a diameter ≤ 10 μm (PM). Patients with SSP were included between June 1, 2009 and May 31, 2013, in 14 Emergency Departments in France. In this case-crossover design study, PM NO, and O data were collected hourly from monitoring stations. Quantitative values, fast increase in air pollutant concentration, and air quality threshold exceedance were retained. These assessments were calculated for each of the 4 days prior to the event (Lag 1-Lag 4) for all case and control period, and for the entire exposure period. A total of 135 patients with SSP were included, with a mean age of 55.56 (SD 18.54) years. For short term exposure of PM, NO and O, no differences were observed between case and control periods in terms of quantitative values of air pollutant exposure (P > 0.68), fast increase in concentration (P > 0.12) or air quality threshold exceedance (P > 0.68). An association between O exposures cannot be ruled out, especially when considering the Lag 2 prior to the event and in warm seasons.
继发性自发性气胸（SSP）发生在潜在肺部疾病的背景下。我们的目的是评估 SSP 与短期空气污染暴露（二氧化氮（NO）、臭氧（O）和直径≤10μm 的颗粒物（PM））之间的关系。2009 年 6 月 1 日至 2013 年 5 月 31 日期间，在法国的 14 个急诊部门纳入了 SSP 患者。在这项病例交叉设计研究中，PM、NO 和 O 数据每小时从监测站收集。保留了定量值、空气污染物浓度的快速增加和空气质量阈值超标。为每个病例和对照期的事件前 4 天（Lag 1-Lag 4）以及整个暴露期计算了这些评估。共纳入了 135 名 SSP 患者，平均年龄为 55.56 岁（标准差 18.54 岁）。对于 PM、NO 和 O 的短期暴露，在污染物暴露的定量值方面，病例期和对照期之间没有差异（P>0.68），浓度的快速增加（P>0.12）或空气质量阈值超标（P>0.68）。不能排除 O 暴露之间的关联，尤其是在事件发生前的第 2 天和温暖季节考虑时。
