病原体干扰：针对毒力因子以应对细胞内微生物。
Pathogen Interference: Targeting Virulence Factors to Tackle Intracellular Microbes.
机构信息
Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA.
Division of Host-Microbe Systems & Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA; Center for Microbiome Innovation, University of California San Diego, La Jolla, CA 92093, USA; Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines (CU-UCSD cMAV), La Jolla, CA 92093, USA.
出版信息
Cell Chem Biol. 2020 Jul 16;27(7):765-767. doi: 10.1016/j.chembiol.2020.06.017.
Infections with Salmonella enterica pose a challenge for antibiotic treatment. In this issue of Cell Chemical Biology, Tsai et al. use a chemical genomics approach to identify dephostatin as an inhibitor of intracellular Salmonella virulence in vitro and in vivo by targeting the two-component systems SsrA-SsrB and PmrB-PmrA.
肠沙门氏菌感染对抗生素治疗构成挑战。在本期《细胞化学生物学》中，Tsai 等人采用化学基因组学方法，通过靶向双组分系统 SsrA-SsrB 和 PmrB-PmrA，发现了 dephostatin 是一种体外和体内抑制沙门氏菌毒力的抑制剂。
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