Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong Province, PR China.
Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, Guangdong Province, PR China.
Nanomedicine. 2020 Oct;29:102269. doi: 10.1016/j.nano.2020.102269. Epub 2020 Jul 15.
X-ray CT imaging can be complementary to fluorescence and photoacoustic imaging (FLI and PAI), allowing for high spatial resolution and high-sensitivity multimodal imaging for imaging guided treatment. In this study, the CT contrast agent iohexol was co-encapsulated with indocyanine green (ICG) within nanoliposomes (NLs) to explore their interaction and possible application of this liposomal formulation (LGI) in cancer theranostics. The photophysical properties of LGI were studied to assess the effect of iohexol on ICG that can enhance the efficiency of ICG-based near infrared photodynamic therapy (PDT). The CT, FLI and PA imaging abilities of LGI were also investigated. Furthermore, the near infrared phototherapy of cancer cells in vitro was performed, exhibiting higher phototherapy efficacy of LGI in comparison with other ICG formulations. We conclude that LGI can serve as a highly efficient theranostic nanoplatform for multimodal (fluorescence, CT and PA) imaging and near infrared phototherapy.
X 射线 CT 成像是荧光和光声成像（FLI 和 PAI）的补充，可以实现高空间分辨率和高灵敏度的多模态成像，用于成像引导治疗。在这项研究中，将碘海醇与吲哚菁绿（ICG）共包封在纳米脂质体（NLs）内，以探索其相互作用和这种脂质体制剂（LGI）在癌症治疗学中的可能应用。研究了 LGI 的光物理性质，以评估碘海醇对 ICG 的影响，这可以提高基于 ICG 的近红外光动力疗法（PDT）的效率。还研究了 LGI 的 CT、FLI 和 PA 成像能力。此外，还进行了体外癌细胞的近红外光疗，结果表明 LGI 的光疗效果比其他 ICG 制剂更高。我们得出结论，LGI 可以作为一种高效的多模态（荧光、CT 和 PA）成像和近红外光疗的治疗诊断纳米平台。
