Department of Dermatology, Park Nicollet Health Services, Minneapolis, Minnesota; Department of Dermatology, University of Minnesota, Minneapolis, Minnesota; Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota.
Department of Dermatology, Park Nicollet Health Services, Minneapolis, Minnesota; Department of Dermatology, Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota; University of Minnesota Medical School, Minneapolis, Minnesota.
J Am Acad Dermatol. 2021 Apr;84(4):953-964. doi: 10.1016/j.jaad.2020.07.020. Epub 2020 Jul 15.
Eyelid dermatitis is a common dermatologic complaint.
To characterize patients with eyelid dermatitis.
Retrospective analysis (1994-2016) of North American Contact Dermatitis Group data.
Of 50,795 patients, 2332 (4.6%) had eyelid dermatitis only, whereas 1623 (3.2%) also had dermatitis of the eyelids and head or neck. Compared with patients without eyelid involvement (n = 26,130), groups with eyelid dermatitis only and dermatitis of the eyelid and head or neck were significantly more likely to be female, white, and older than 40 years, and to have a history of hay fever, atopic dermatitis, or both (P < .01). Final primary diagnoses included allergic contact dermatitis (eyelid dermatitis only: 43.4%; dermatitis of the eyelid and head or neck: 53.5%), irritant contact dermatitis (eyelid dermatitis only: 17.0%; dermatitis of the eyelid and head or neck: 9.8%), and atopic dermatitis (eyelid dermatitis only: 13.1%; dermatitis of the eyelid and head or neck: 13.8%). Top 5 currently relevant allergens included nickel sulfate (eyelid dermatitis only: 18.6%; dermatitis of the eyelid and head or neck: 22.5%), fragrance mix I (eyelid dermatitis only: 16.5%; dermatitis of the eyelid and head or neck: 18.3%), methylisothiazolinone (eyelid dermatitis only: 16.5%; dermatitis of the eyelid and head or neck: 17.7%), gold sodium thiosulfate (eyelid dermatitis only: 14.7%; dermatitis of the eyelid and head or neck: 11.4%), and balsam of Peru (eyelid dermatitis only: 11.9%; dermatitis of the eyelid and head or neck: 12.6%). Both eyelid-involvement groups were significantly more likely to react to gold sodium thiosulfate, carmine, shellac, dimethylaminopropylamine, oleamidopropyl dimethylamine, and thimerosal (P < .05) compared with the no eyelid involvement group.
Lack of specific distribution patterns of eyelid dermatitis and no long-term follow-up data.
Patch testing remains a critical tool in evaluating patients with eyelid dermatitis.
眼睑皮炎是一种常见的皮肤科疾病。
描述患有眼睑皮炎的患者的特征。
回顾性分析（1994-2016 年）北美接触性皮炎组的数据。
在 50795 名患者中，2332 名（4.6%）仅患有眼睑皮炎，而 1623 名（3.2%）还患有眼睑和头颈部皮炎。与无眼睑受累的患者（n=26130 名）相比，仅患有眼睑皮炎和眼睑及头颈部皮炎的两组患者更有可能为女性、白人且年龄大于 40 岁，并且更有可能患有枯草热、特应性皮炎或两者兼有（P<.01）。最终的主要诊断包括过敏性接触性皮炎（仅眼睑皮炎：43.4%；眼睑和头颈部皮炎：53.5%）、刺激性接触性皮炎（仅眼睑皮炎：17.0%；眼睑和头颈部皮炎：9.8%）和特应性皮炎（仅眼睑皮炎：13.1%；眼睑和头颈部皮炎：13.8%）。前 5 种目前相关的过敏原包括硫酸镍（仅眼睑皮炎：18.6%；眼睑和头颈部皮炎：22.5%）、香料混合物 I（仅眼睑皮炎：16.5%；眼睑和头颈部皮炎：18.3%）、甲基异噻唑啉酮（仅眼睑皮炎：16.5%；眼睑和头颈部皮炎：17.7%）、金钠硫代硫酸（仅眼睑皮炎：14.7%；眼睑和头颈部皮炎：11.4%）和秘鲁香脂（仅眼睑皮炎：11.9%；眼睑和头颈部皮炎：12.6%）。两组眼睑受累患者对金钠硫代硫酸、胭脂红、虫胶、二甲氨基丙胺、油酰胺基丙基二甲胺和硫柳汞的反应明显更频繁（P<.05），而与无眼睑受累组相比。
缺乏眼睑皮炎的特定分布模式和缺乏长期随访数据。
斑贴试验仍然是评估眼睑皮炎患者的重要工具。
